지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.3
- 수록면
- 12 - 18 (7page)
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초록· 키워드
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The present study aimed to quantitatively compare the normal and diabetic hearts of rats using stereological methods. Diabetic and control rats received streptozotocin (60 mg/kg) and no treatments, respectively. On the 56<sup>th</sup> day, the hearts were removed and their total volume was estimated using isotropic Cavalieri method. The total volume of the connective tissues and vessels, total length and diameter of the vessels, total number of cardiomyocytes nuclei, and the mean volume of the cardiomyocytes were estimated, as well. In comparison to the control animals, 60 and 43% increase was observed in the total volume of the connective tissue and microvessels of the diabetic rats, respectively (P<0.05). The percent of the vessel profiles with the diameter of 2-4 μm was decreased, while the percent of the vessel profiles with the diameter of 4.1-8 μm was increased in the diabetic hearts (P<0.05). No significant difference was found in the vessels with more than 8 μm diameters. The total number of the cardiomyocytes" nuclei and the number-weighted mean volume were respectively decreased by 37 and 64% in the diabetic group (P<0.01). A significant difference was observed between the two groups concerning the left ventricle volume to body weight ratio as an index for ventricular hypertrophy (P<0.05), while no difference was found regarding the right ventricle to body weight ratio. It can be concluded that diabetes can induce structural changes, including loss and/or atrophy of the cardiomyocytes, accompanied with increase in the connective tissue in the rats" hearts.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Cheng YZ / 2012 / Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats / J Ethnopharmacol 144 (2) : 234 ~ 239
2. [학술지(정기간행물)] - Wang J / 2006 / Causes and characteristics of diabetic cardiomyopathy / Rev Diabet Stud 3 (3) : 108 ~ 117
3. [학술지(정기간행물)] - Kannel WB / 1974 / Role of diabetes in congestive heart failure: the Framingham study / Am J Cardiol 34 (1) : 29 ~ 34
4. [학술지(정기간행물)] - Abbott RD / 1988 / The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study / JAMA 260 (23) : 3456 ~ 3460
5. [학술지(정기간행물)] - Rubler S / 1972 / New type of cardiomyopathy associated with diabetic glomerulosclerosis / Am J Cardiol 30 (6) : 595 ~ 602
2. [학술지(정기간행물)] - Wang J / 2006 / Causes and characteristics of diabetic cardiomyopathy / Rev Diabet Stud 3 (3) : 108 ~ 117
3. [학술지(정기간행물)] - Kannel WB / 1974 / Role of diabetes in congestive heart failure: the Framingham study / Am J Cardiol 34 (1) : 29 ~ 34
4. [학술지(정기간행물)] - Abbott RD / 1988 / The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study / JAMA 260 (23) : 3456 ~ 3460
5. [학술지(정기간행물)] - Rubler S / 1972 / New type of cardiomyopathy associated with diabetic glomerulosclerosis / Am J Cardiol 30 (6) : 595 ~ 602
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UCI(KEPA) : I410-ECN-0101-2014-500-003007725