지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.84 No.4
- 발행연도
- 2013.4
- 수록면
- 216 - 224 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Few studies have examined whether bioengineering can improve fecal incontinence. This study designed to determine whether injection of porous polycaprolactone beads containing autologous myoblasts improves sphincter function in a dog model of fecal incontinence. Methods: The anal sphincter of dogs was injured and the dogs were observed without and with (n = 5) the injection of porous polycaprolactone beads containing autologous myoblasts into the site of injury. Autologous myoblasts purified from the gastrocnemius muscles were transferred to the beads. Compound muscle action potentials (CMAP) of the pudendal nerve, anal sphincter pressure, and histopathology were determined 3 months after treatment. Results: The amplitudes of the CMAP in the injured sphincter were significantly lower than those measured before injury (1.22 mV vs. 3.00 mV, P = 0.04). The amplitudes were not different between dogs with and without the injection of autologous myoblast beads (P = 0.49). Resting and squeezing pressures were higher in dogs treated with autologous myoblast beads (2.00 mmHg vs. 1.80 mmHg; 6.13 mmHg vs. 4.02 mmHg), although these differences were not significant in analyses of covariance adjusted for baseline values. The injection site was stained for smooth muscle actin, but showed evidence of foreign body inflammatory reactions. Conclusion: This was the first study to examine whether bioengineering could improve
fecal incontinence. Although the results did not show definite evidence that injection of autologous myoblast beads improves sphincter function, we found that the dog model was suitable and reliable for studying the effects of a potential treatment modality for fecal incontinence.
fecal incontinence. Although the results did not show definite evidence that injection of autologous myoblast beads improves sphincter function, we found that the dog model was suitable and reliable for studying the effects of a potential treatment modality for fecal incontinence.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Nelson R / 1995 / Community- based prevalence of anal incontinence / JAMA 274 : 559 ~ 561
2. [학술지(정기간행물)] - Macmillan AK / 2004 / The prevalence of fecal incontinence in community-dwelling adults: a systematic review of the literature / Dis Colon Rectum 47 : 1341 ~ 1349
3. [학술지(정기간행물)] - Roberts RO / 1999 / Prevalence of combined fecal and urinary incontinence: a community-based study / J Am Geriatr Soc 47 : 837 ~ 841
4. [학술지(정기간행물)] - Ito M / 2009 / Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer / Dis Colon Rectum 52 : 64 ~ 70
5. [학술지(정기간행물)] - Wald A. / 2007 / Clinical practice: fecal incontinence in adults / N Engl J Med 356 : 1648 ~ 1655
2. [학술지(정기간행물)] - Macmillan AK / 2004 / The prevalence of fecal incontinence in community-dwelling adults: a systematic review of the literature / Dis Colon Rectum 47 : 1341 ~ 1349
3. [학술지(정기간행물)] - Roberts RO / 1999 / Prevalence of combined fecal and urinary incontinence: a community-based study / J Am Geriatr Soc 47 : 837 ~ 841
4. [학술지(정기간행물)] - Ito M / 2009 / Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer / Dis Colon Rectum 52 : 64 ~ 70
5. [학술지(정기간행물)] - Wald A. / 2007 / Clinical practice: fecal incontinence in adults / N Engl J Med 356 : 1648 ~ 1655
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UCI(KEPA) : I410-ECN-0101-2014-510-003019554