지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 201 - 209 (9page)
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초록· 키워드
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Ginsenoside, one of the active ingredients of Panax ginseng, has a variety of physiologic and pharmacologic effects. The purpose of this study was to explore the effects of ginsenoside Rd (G-Rd) on melastatin type transient receptor potential 7 (TRPM7) channels with respect to the proliferation and survival of AGS and MCF-7 cells (a gastric and a breast cancer cell line, respectively). AGS and MCF-7 cells were treated with different concentrations of G-Rd, and caspase-3 activities, mitochondrial depolarizations, and sub-G1 fractions were analyzed to determine if cell death occurred by apoptosis. In addition, human embryonic kidney (HEK) 293 cells overexpressing TRPM7 channels were used to confirm the role of TRPM7 channels. G-Rd inhibited the proliferation and survival of AGS and MCF-7 cells and enhanced caspase-3 activity, mitochondrial depolarization, and sub-G1 populations. In addition, G-Rd inhibited TRPM7-like currents in AGS and MCF-7 cells and in TRPM7 channel overexpressing HEK 293 cells, as determined by whole cell voltage-clamp recordings. Furthermore, TRPM7 overexpression in HEK 293 cells promoted G-Rd induced cell death. These findings suggest that G-Rd inhibits the proliferation and survival of gastric and breast cancer cells by inhibiting TRPM7 channel activity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (41)
참고문헌 신청
1. [학술지(정기간행물)] - Kim HS / 2007 / Effects of ginseng total saponins on pacemaker currents of interstitial cells of Cajal from the small intestine of mice / Biol Pharm Bull 30 : 2037 ~ 2042
2. [학술지(정기간행물)] - Kim BJ / 2008 / Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer / Cancer Sci 99 : 2502 ~ 2509
3. [학술지(정기간행물)] - Guilbert A / 2009 / Evidence that TRPM7 is required for breast cancer cell proliferation / Am J Physiol Cell Physiol 297 : C493 ~ C502
4. [학술지(정기간행물)] - Clapham DE. / 2003 / TRP channels as cellular sensors / Nature 426 : 517 ~ 524
5. [학술지(정기간행물)] - Nadler MJ / 2001 / LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability / Nature 411 : 590 ~ 595
2. [학술지(정기간행물)] - Kim BJ / 2008 / Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer / Cancer Sci 99 : 2502 ~ 2509
3. [학술지(정기간행물)] - Guilbert A / 2009 / Evidence that TRPM7 is required for breast cancer cell proliferation / Am J Physiol Cell Physiol 297 : C493 ~ C502
4. [학술지(정기간행물)] - Clapham DE. / 2003 / TRP channels as cellular sensors / Nature 426 : 517 ~ 524
5. [학술지(정기간행물)] - Nadler MJ / 2001 / LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability / Nature 411 : 590 ~ 595
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UCI(KEPA) : I410-ECN-0101-2014-520-003018753