지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.3
- 수록면
- 15 - 19 (5page)
이용수
초록· 키워드
오류제보하기
Alloxan administration in rats is used as a model for non-insulin dependent diabetes mellitus (NIDDM). NIDDM is a multifactorial disease, characterized by hyperglycemia and lipoprotein abnormalities. In this study, we evaluated the antihyperglycemic and antihyperlipidemic effects of fermented Rhynchosia nulubilis (FRN) through the regulation of glucose uptake in alloxan-induced rats. Fermented R. nulubilis was administered orally for 28 d at 500 mg/kg of body weight. Body weight and food intake were monitored every day. Biochemical parameters were quantified after 4 week. In the diabetic + FRN group, body weight increased significantly and blood glucose concentrations decreased when compared to those of the diabetic group. After 2 hr of administration, the oral glucose tolerance test (OGTT) indicated a significant reduction in the diabetic + FRN group compared to diabetic group. The diabetic + FRN group experienced a significant reduction in total cholesterol, triglycerides, low density lipoprotein, coronary risk factors, and malondialdehyde concentrations, with significantly increased high density lipoprotein compared to those of diabetic group. These results demonstrate that fermented R. nulubilis possesses potent antihyperglycemic and antihyperlipidemic activity in alloxan-induced diabetic rats.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
Wild, S. / 2004 / Global prevalence of diabetes: estimate for the year 2000 and projections for 2030 / Diabetes Care 27:1047~1053
Arokiyaraj, S. / 2011 / Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats / Asian Pac. J. Trop. Med 1:386~390
Adeneye, A. A. / 2008 / Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of Morinda Lucida Benth. in normal and alloxan-induced diabetic rats / Afr. J. Biomed. Res. 11:65~71
Ojezele, M.O. / 2011 / Hypoglycaemic and coronary risk index lowering effects of Bauhinia thoningiiin alloxan induced diabetic rats / Afr. Health Sci. 11:85~89
Zhang, H. N. / 2003 / In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage / Life Sci. 73:2307~2319
Arokiyaraj, S. / 2011 / Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats / Asian Pac. J. Trop. Med 1:386~390
Adeneye, A. A. / 2008 / Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of Morinda Lucida Benth. in normal and alloxan-induced diabetic rats / Afr. J. Biomed. Res. 11:65~71
Ojezele, M.O. / 2011 / Hypoglycaemic and coronary risk index lowering effects of Bauhinia thoningiiin alloxan induced diabetic rats / Afr. Health Sci. 11:85~89
Zhang, H. N. / 2003 / In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage / Life Sci. 73:2307~2319
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UCI(KEPA) : I410-ECN-0101-2014-510-003159904