지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.3
- 수록면
- 7 - 14 (8page)
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초록· 키워드
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Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in diabetic db/db mice. Alleviation of endoplasmic reticulum (ER) and oxidative stress was also examined in the livers and brains of db/db mice fed a betaine-supplemented diet. Male C57BL/KsJ-db/db mice were fed with or without 1% betaine for 5 wk (referred to as the db/db-betaine group and the db/db group, respectively). Lean non-diabetic db/+ mice were used as the control group. Betaine supplementation significantly alleviated hyperinsulinemia in db/db mice. Betaine reduced hepatic expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha, a major transcription factor involved in gluconeogenesis. Lower serum triglyceride concentrations were also observed in the db/db-betaine group compared to the db/db group. Betaine supplementation induced hepatic peroxisome proliferator-activated receptor alpha and carnitine palmitoyltransferase 1a mRNA levels, and reduced acetyl-CoA carboxylase activity. Mice fed a betaine-supplemented diet had increased total glutathione concentrations and catalase activity, and reduced lipid peroxidation levels in the liver. Furthermore, betaine also reduced ER stress in liver and brain. c-Jun N-terminal kinase activity and tau hyperphosphorylation levels were lower in db/db mice fed a betaine-supplemented diet, compared to db/db mice. Our findings suggest that betaine improves hyperlipidemia and tau hyperphosphorylation in db/db mice with insulin resistance by alleviating ER and oxidative stress.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
Kumashiro, N. / 2008 / Impact of oxidative stress and peroxisome proliferatoractivated receptor gamma coactivator-1alpha in hepatic insulin resistance / Diabetes 57:2083~2091
Ozcan, U. / 2004 / Endoplasmic reticulum stress links obesity, insulin action, and type 2 / diabetes. Sci 306:457~461
Nakatani, Y. / 2005 / Involvement of endoplasmic reticulum stress in insulin resistance and diabetes / J. Biol. Chem 280:847~851
Han, M. S. / 2009 / Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice / Diabetes 58:329~336
Han, K. L. / 2008 / Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes / Diabetes 57:737~745
Ozcan, U. / 2004 / Endoplasmic reticulum stress links obesity, insulin action, and type 2 / diabetes. Sci 306:457~461
Nakatani, Y. / 2005 / Involvement of endoplasmic reticulum stress in insulin resistance and diabetes / J. Biol. Chem 280:847~851
Han, M. S. / 2009 / Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice / Diabetes 58:329~336
Han, K. L. / 2008 / Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes / Diabetes 57:737~745
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UCI(KEPA) : I410-ECN-0101-2014-510-003159893