지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.3
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and genetic analyses. Basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination using suitable animal models of disease. However, in the past two decades new technologies have been developed that permit the imaging of live animals using radiotracer emission, Xrays, magnetic resonance signals, fluorescence, and bioluminescence. The main objective of this review is to provide an overview of small animal molecular imaging, with a focus on nuclear imaging (single photon emission computed tomography and positron emission tomography). These technologies permit visualization of toxicodynamics as well as toxicity to specific organs by directly monitoring drug accumulation and assessing physiological and/or molecular alterations. Nuclear imaging technology has great potential for improving the efficiency of the drug development process.
목차
INTRODUCTION
MOLECULAR IMAGING
SMALL ANIMAL MOLECULAR IMAGING MODALITIES
NUCLEAR IMAGING
IMAGING PROBES FOR MOLECULAR IMAGING
IDENTIFICATION OF SUITABLE TARGETS FOR MOLECULAR IMAGING
LABELING A LIGAND THAT BINDS TO A MOLECULAR TARGET
DELIVERY OF PROBE
APPLICATION OF NUCLEAR IMAGING FOR DRUG DISCOVERY AND DEVELOPMENT
APPLICATION OF NUCLEAR IMAGING FOR TOXICITY STUDY
CONCLUSION
REFERENCES
참고문헌 (35)
참고문헌 신청
DiMasi, J. A. / 2003 / The price of innovation: new estimates of drug development costs / J. Health Econ 22:151~185
Ahn, B. C. / 2011 / Applications of molecular imaging in drug discovery and development process / Curr. Opin. Biotechnol 12:459~468
Rudin, M. / 2009 / Noninvasive structural, fuctional, and molecular imaging in drug development / Curr. Opin. Chem. Biol 13:360~371
Czernin, J. / 2006 / Molecular imaging in development of cancer therapeutics / Annu. Rev. Med 57:99~118
Rudin, M. / 2003 / Molecular imaging in drug discovery and development / Nat. Rev. Drug Discov 2:123~131
Ahn, B. C. / 2011 / Applications of molecular imaging in drug discovery and development process / Curr. Opin. Biotechnol 12:459~468
Rudin, M. / 2009 / Noninvasive structural, fuctional, and molecular imaging in drug development / Curr. Opin. Chem. Biol 13:360~371
Czernin, J. / 2006 / Molecular imaging in development of cancer therapeutics / Annu. Rev. Med 57:99~118
Rudin, M. / 2003 / Molecular imaging in drug discovery and development / Nat. Rev. Drug Discov 2:123~131
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UCI(KEPA) : I410-ECN-0101-2014-510-003159888