지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 717 - 728 (12page)
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초록· 키워드
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This study was designed to clarify an association of ACE polymrophism with bone mineral density(BMD), bone strength, and basal physical fitness in elderly women. We determined the ACE polymorphism using a polymerase chain reaction(PCR), in a DNA sample of 64 elderly women aged 75.4 ± 8.5 yrs. The genetic subtype was characterized by the presence(insertion, I allele) or absence(deletion, D allele) of a 287 base pair fragment and then BMD, bone strength and basal physical fitness were compared among genotypes. A densitometric studies on lumbar spine and femur and analyses of ultrasonic wave in calcaneus were performed. For the genotype distribution, 34.4%(n = 22) were II genotype, 42.2%(n = 27) were ID genotype and 23.4%(n = 15) were DD genotype, respectively. The lumbar vertebra 1 (L1) BMD of II genotype was significantly 19.5% higher than that of DD genotype(p < .05), and L4 BMD of II genotype was also significantly 18.5% higher than that of DD genotype(p < .05). Resting heart rate of II genotype was significantly lower than that of ID genotype(p < .05), and no differences were observed in basal physical fitness. Although a moderate negative correlation was found between age and femur BMD, calcaneus bone strength(p < .05), a positive correlation was found between muscle mass and lumbar and femur BMD(p < .05, p < .01). These results suggest that ACE gene polymorphism might be used as a one of genetic determinants of bone mass in elderly women.
목차
Abstract
1. 서론
2. 연구방법 및 측정항목
3. 결과
4. 고찰
5. 결론
인용문헌
참고문헌 (45)
참고문헌 신청
1. [기타자료] - 통계청 / 2011 / 2011 고령자통계
2. [학술지(정기간행물)] - Altun B. / 2004 / Association between activated renin angiotensin system and bone formation in hemodialysis patients: is the bone mass genetically determined by ACE gene polymorphism? / Ren. Fail. 26 (4) : 425 ~ 431
3. [학술지(정기간행물)] - Alvarez R. / 2000 / Genetic variation in the renin-angiotensin system and athletic performance / Eur. J. Appl. Physiol. 82 (1-2) : 117 ~ 120
4. [학술지(정기간행물)] - Arden, N. K. / 1997 / Genetic influences on muscle strength, lean body mass, and bone mineral density : a twin study / J. Bone. Miner. Res. 12 (12) : 2076 ~ 2081
5. [학술지(정기간행물)] - Cammarata, P. R. / 2004 / Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells / Exp Eye Res 78 (4) : 861 ~ 871
2. [학술지(정기간행물)] - Altun B. / 2004 / Association between activated renin angiotensin system and bone formation in hemodialysis patients: is the bone mass genetically determined by ACE gene polymorphism? / Ren. Fail. 26 (4) : 425 ~ 431
3. [학술지(정기간행물)] - Alvarez R. / 2000 / Genetic variation in the renin-angiotensin system and athletic performance / Eur. J. Appl. Physiol. 82 (1-2) : 117 ~ 120
4. [학술지(정기간행물)] - Arden, N. K. / 1997 / Genetic influences on muscle strength, lean body mass, and bone mineral density : a twin study / J. Bone. Miner. Res. 12 (12) : 2076 ~ 2081
5. [학술지(정기간행물)] - Cammarata, P. R. / 2004 / Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells / Exp Eye Res 78 (4) : 861 ~ 871
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UCI(KEPA) : I410-ECN-0101-2014-500-002375897