지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2012.11
- 수록면
- 644 - 647 (4page)
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초록· 키워드
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In this paper, we propose and fabricate a magnetic-force induced cell filtration device using ferromagnetic iron oxide composites. The present device not only prohibits clogging between mechanical structures and particles, but also enables filtration of small and deformable particles which is not achieved without extremely small and robust structures. The micro-tapered structures made of ferromagnetic iron oxide composites generate differences of local magnetic fields by external magnetic fields. Diamagnetic microparticles such as blood cells and tumor cells can be filtered by the repulsion forces in the micro-tapered structures because of the local magnetic forces originated by the local differences of the magnetic fields. For demonstrating the magnetic-force induced cell filtration, we prepare filtration experiments using cell mixture of whole bloods(most of blood cells are under 10㎛-diameter) from healthy volunteer and lung cancer cells from A549 cell-line(diameters of about 20㎛). The samples are diluted with PBS(Phosphate Buffered Saline) buffer, thus, effective dilution factor of blood is 1:1 and population of A549 is maintained as 1×10?/㎖. In the 1㎖/hr of sample injection rate, without external magnetic fields, most cells pass the micro-tapered structures, however, with external magnetic fields; most cells cannot pass the micro-tapered structures. Therefore, the present magnetic-force induced cell filtration method enables prohibiting clogging problems and separation of small and deformable particles such as blood cells. Future work will be about optimizing the device performances of the proposed concept.
목차
Abstract
1. 서론
2. 이론적 배경
3. 소자 설계 및 제작
4. 실험적 검증
5. 결론 및 향후 계획
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UCI(KEPA) : I410-ECN-0101-2014-550-000188261