지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : This experiment was conducted to evaluate the inhibitory effects against lung metastasis and promotion of splenocytes by water-soluble components from five mushrooms extracts (WEFM): Garnoderma frondosa, Corious versicolor, Codyceps militaris, Hericium erinaceus and Lentinula edodes.
Methods : Colon 26-L5 carcinoma cells were injected through the tail vein to induce lung metastatic cancer. Changes in weight of lung were observed and cytokine level was analyzed to evaluate immunological changes.
Results : Oral administration of WEFM resulted in a significant inhibition of lung metastasis after intravenous injection of colon 26-L5 cells in a dose-dependent manner. There was also a significant increase in T cell and B cell mitogenic stimuli and production of IFN-g by splenocytes stimulated with Con A compared to untreated controls.
Conclusion : WEFM may have anti-tumor activities via Th1-type dominant immune responses.
Methods : Colon 26-L5 carcinoma cells were injected through the tail vein to induce lung metastatic cancer. Changes in weight of lung were observed and cytokine level was analyzed to evaluate immunological changes.
Results : Oral administration of WEFM resulted in a significant inhibition of lung metastasis after intravenous injection of colon 26-L5 cells in a dose-dependent manner. There was also a significant increase in T cell and B cell mitogenic stimuli and production of IFN-g by splenocytes stimulated with Con A compared to untreated controls.
Conclusion : WEFM may have anti-tumor activities via Th1-type dominant immune responses.
목차
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Sorimachi K / 1995 / Secretion of TNF-alpha from macrophages following induction with a lignin derivative / Cell Biol Int 19 (10) : 833 ~ 838
2. [학술지(정기간행물)] - Lee SJ / 2003 / Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang / Int Immunopharmacol 3 (2) : 147 ~ 157
3. [학술지(정기간행물)] - Ohnishi Y / 1998 / Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells / Jpn J Cancer Res 89 (2) : 206 ~ 213
4. [학술지(정기간행물)] - Harada M / 1995 / Concomitant immunity against tumor development is enhanced by the oral administration of a kampo medicine, Hochu-ekki-to (TJ-41: Bu-Zhong-Yi-Qi-Tang) / Immunopharmacol Immunotoxicol 17 (4) : 687 ~ 703
5. [학술지(정기간행물)] - Zaidman BZ / 2005 / Medicinal mushroom modulators of molecular targets as cancer therapeutics / Appl Microbiol Biotechnol 67 (4) : 453 ~ 468
2. [학술지(정기간행물)] - Lee SJ / 2003 / Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang / Int Immunopharmacol 3 (2) : 147 ~ 157
3. [학술지(정기간행물)] - Ohnishi Y / 1998 / Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells / Jpn J Cancer Res 89 (2) : 206 ~ 213
4. [학술지(정기간행물)] - Harada M / 1995 / Concomitant immunity against tumor development is enhanced by the oral administration of a kampo medicine, Hochu-ekki-to (TJ-41: Bu-Zhong-Yi-Qi-Tang) / Immunopharmacol Immunotoxicol 17 (4) : 687 ~ 703
5. [학술지(정기간행물)] - Zaidman BZ / 2005 / Medicinal mushroom modulators of molecular targets as cancer therapeutics / Appl Microbiol Biotechnol 67 (4) : 453 ~ 468
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UCI(KEPA) : I410-ECN-0101-2014-519-000263662