지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study was undertaken to evaluate anti-glycemic and anti-lipid effects of Supungsunkihwan-gagambang, which is composed of Cornus officinalis, Dioscorea Batatas Decaisne, Auantii fructus and Platicodon grandiflorum.
Methods: Diabetes was induced in ICR male mice (24±1g) with Surwit’s high fat and high sucrose diet. Mice were divided into 3 groups (n=10) of normal, control and Supungsunkihwan-gagambang. The Supungsunkihwan-gagambang group was given 5% herbal medicine in their diet. The animals were fed on each experimental diet for 8 weeks. Body weight was assessed every week. At the 7th week, the fasting blood sugar (FBS) and oral glucose tolerance test (OGTT) were conducted in all experimental groups. After 8 weeks, fructosamine, lipid profile, epididymal fat weight, liver weight and white adipose tissue (WAT) size were measured.
Results: Supungsunkihwan-gagambang significantly reduced FBS, OGTT and fructosamine. It also increased high density lipoprotein (HDL) cholesterol and significantly reduced triglyceride/HDL cholesterol ratio, total cholesterol/HDL cholesterol ratio and WAT size.
Conclusions: These results show that Supungsunkihwan-gagambang improves anti-glycemic and anti-lipid effect in high fat diet-induced obese mice. Therefore we suggest that Supungsunkihwan-gagambang could be an effective treatment for patients with type 2 diabetes.
Methods: Diabetes was induced in ICR male mice (24±1g) with Surwit’s high fat and high sucrose diet. Mice were divided into 3 groups (n=10) of normal, control and Supungsunkihwan-gagambang. The Supungsunkihwan-gagambang group was given 5% herbal medicine in their diet. The animals were fed on each experimental diet for 8 weeks. Body weight was assessed every week. At the 7th week, the fasting blood sugar (FBS) and oral glucose tolerance test (OGTT) were conducted in all experimental groups. After 8 weeks, fructosamine, lipid profile, epididymal fat weight, liver weight and white adipose tissue (WAT) size were measured.
Results: Supungsunkihwan-gagambang significantly reduced FBS, OGTT and fructosamine. It also increased high density lipoprotein (HDL) cholesterol and significantly reduced triglyceride/HDL cholesterol ratio, total cholesterol/HDL cholesterol ratio and WAT size.
Conclusions: These results show that Supungsunkihwan-gagambang improves anti-glycemic and anti-lipid effect in high fat diet-induced obese mice. Therefore we suggest that Supungsunkihwan-gagambang could be an effective treatment for patients with type 2 diabetes.
목차
서론
실험방법
연구 결과
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결론
감사의 글
참고문헌
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Baek SH / 2007 / Prevention of Type 2 diabetes / Medical Postgraduates 3 : 128 ~ 131
2. [학술지(정기간행물)] - Haffner SM / 1990 / Patterson JK. Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes / JAMA 263 : 2893 ~ 2898
3. [학술지(정기간행물)] - Chiasson JL / 2003 / Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial / JAMA 290 (4) : 486 ~ 494
4. [학술지(정기간행물)] - Vetrichelvan T / 2002 / Anti-diabetic activity of alcoholic extract of Aerva lanata(L.) Juss.ex Schultes in rats / J Ethnopharm 80 : 103 ~ 107
5. [인터넷자원] - / / http://www.diabetes.or.kr/notice/list.php?code= broad
2. [학술지(정기간행물)] - Haffner SM / 1990 / Patterson JK. Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes / JAMA 263 : 2893 ~ 2898
3. [학술지(정기간행물)] - Chiasson JL / 2003 / Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial / JAMA 290 (4) : 486 ~ 494
4. [학술지(정기간행물)] - Vetrichelvan T / 2002 / Anti-diabetic activity of alcoholic extract of Aerva lanata(L.) Juss.ex Schultes in rats / J Ethnopharm 80 : 103 ~ 107
5. [인터넷자원] - / / http://www.diabetes.or.kr/notice/list.php?code= broad
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UCI(KEPA) : I410-ECN-0101-2014-519-000262261