지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: HMCO5 is an extract obtained from 8 different herbal mixtures. We undertook a safety evaluation of HMCO5 for a dose range finding (DRF) toxicity test in specific pathogen free (SPF) Sprague-Dawley (SD) male and female rats.
Methods: The male and female rats were divided into 4 groups, respectively; G(0), treated with distilled water: G(1), treated with 222 mg/kg HMC05: G(2), treated with 667 mg/kg HMC05, and G(3), treated with 2,000 mg/kg HMC05; HMC05 was administered orally for 4 weeks. The safety evaluation examined clinical signs, mortality, body weight, food consumption, water consumption, ophthalmic findings, urinalysis, hematological values, absolute & relative organ weights, and necropsy findings during the tests.
Results: There were no changes in clinical signs, mortality, body weight, food consumption, water consumption, and ophthalmic findings examined during the test periods. In serum biochemical values, triglyceride was increased in male group G(3) and Na+decreased significantly in male groups G(2), G(3) and G(4). In male group G(4), spleen weight decreased relatively and increases of absolute & relative left ovary weights were found. In addition, an adhesion of liver to diaphragm was found in male group G(2). However, we could not find any dose-interrelationships in these changes.
Conclusions: These results indicate that HMC05 extract did not show any toxicity in the DRF toxicity study. Therefore, it suggests that establishment of 1,000, 333 and 111 mg/kg dosages are moderate in a repeated dose 26-week oral toxicity study of HMC05.
Methods: The male and female rats were divided into 4 groups, respectively; G(0), treated with distilled water: G(1), treated with 222 mg/kg HMC05: G(2), treated with 667 mg/kg HMC05, and G(3), treated with 2,000 mg/kg HMC05; HMC05 was administered orally for 4 weeks. The safety evaluation examined clinical signs, mortality, body weight, food consumption, water consumption, ophthalmic findings, urinalysis, hematological values, absolute & relative organ weights, and necropsy findings during the tests.
Results: There were no changes in clinical signs, mortality, body weight, food consumption, water consumption, and ophthalmic findings examined during the test periods. In serum biochemical values, triglyceride was increased in male group G(3) and Na+decreased significantly in male groups G(2), G(3) and G(4). In male group G(4), spleen weight decreased relatively and increases of absolute & relative left ovary weights were found. In addition, an adhesion of liver to diaphragm was found in male group G(2). However, we could not find any dose-interrelationships in these changes.
Conclusions: These results indicate that HMC05 extract did not show any toxicity in the DRF toxicity study. Therefore, it suggests that establishment of 1,000, 333 and 111 mg/kg dosages are moderate in a repeated dose 26-week oral toxicity study of HMC05.
목차
서론
실험재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (14)
참고문헌 신청
1. [학술지(정기간행물)] - 이헌재 / 2005 / 半夏白朮天麻湯의 조성에 따른 혈관이완활성과 기전 / 동의생리병리학회지 19 (5) : 1311 ~ 1316
2. [기타자료] - Korean intellectual property office / 2006 / A curing and preventing pharmaceutical composition having an effect of anti-hypertension inducing by containing an extracts of chinese herb, Registration No. 10-0577674
3. [학술지(정기간행물)] - 문국진 / 2008 / HMC05의 혈관이완 활성과 신호전달 작용기전 / 동의생리병리학회지 22 (2) : 315 ~ 320
4. [학술지(정기간행물)] - Kim KM / 2007 / HMCO5, Herbal Extract, Inhibits NF-κB Expression in Lipopolysaccharide Treated Macrophages and Reduces Atherosclerotic Lesions in Cholesterol Fed Mice / Journal of Ethnopharmacology 114 : 316 ~ 324
5. [학술지(정기간행물)] - Kim SH / 2008 / Simultaneous determination of alkaloids and flavonoids in HMC05 preparation by HPLCDAD / Journal of Liquid Chromatography & Related Technologies, Ethnopharmacology 31 : 2917 ~ 2926
2. [기타자료] - Korean intellectual property office / 2006 / A curing and preventing pharmaceutical composition having an effect of anti-hypertension inducing by containing an extracts of chinese herb, Registration No. 10-0577674
3. [학술지(정기간행물)] - 문국진 / 2008 / HMC05의 혈관이완 활성과 신호전달 작용기전 / 동의생리병리학회지 22 (2) : 315 ~ 320
4. [학술지(정기간행물)] - Kim KM / 2007 / HMCO5, Herbal Extract, Inhibits NF-κB Expression in Lipopolysaccharide Treated Macrophages and Reduces Atherosclerotic Lesions in Cholesterol Fed Mice / Journal of Ethnopharmacology 114 : 316 ~ 324
5. [학술지(정기간행물)] - Kim SH / 2008 / Simultaneous determination of alkaloids and flavonoids in HMC05 preparation by HPLCDAD / Journal of Liquid Chromatography & Related Technologies, Ethnopharmacology 31 : 2917 ~ 2926
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UCI(KEPA) : I410-ECN-0101-2014-519-000261835