지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: To investigate anti-inflammatory and anti-arthritic effects of Gyulpidaehwangbakcho-tang (GDBT) extract in a murine model of rheumatoid arthritis.
Methods: The mice received 100㎍ of bovine type II collagen in Freund’s complete adjuvant by intradermal injection at the base of the tail on day 0 and a booster injection on day 21. The mice were orally administered with GDBT (200 or 50㎎/㎏ dissolved in distilled water) daily from day 1 to day 21 after arthritis incidence, and monitored for disease incidence and the severity of arthritis up to day 21. In order to evaluate the effect of GDBT on disease progression, we examined pro-inflammatory cytokines including IL-1β, IL-6, TNF-α, COX-2 and NOS-II.
Results: GDBT produced a significant and dose dependent inhibition of arthritis and inflammation during the entire duration of the study. This action was characterized by the decreased production of IL-1β, IL-6, TNF-α, COX-2, and NOSII in vivo.
Conclusion: We believe that the anti-arthritic activity of GDBT is due to its modulatory effect on the expression of pro-inflammatory cytokine in the synovium. Our results contribute towards validation of the traditional use of GDBT in the treatment of RA and other inflammatory joint disorders.
Methods: The mice received 100㎍ of bovine type II collagen in Freund’s complete adjuvant by intradermal injection at the base of the tail on day 0 and a booster injection on day 21. The mice were orally administered with GDBT (200 or 50㎎/㎏ dissolved in distilled water) daily from day 1 to day 21 after arthritis incidence, and monitored for disease incidence and the severity of arthritis up to day 21. In order to evaluate the effect of GDBT on disease progression, we examined pro-inflammatory cytokines including IL-1β, IL-6, TNF-α, COX-2 and NOS-II.
Results: GDBT produced a significant and dose dependent inhibition of arthritis and inflammation during the entire duration of the study. This action was characterized by the decreased production of IL-1β, IL-6, TNF-α, COX-2, and NOSII in vivo.
Conclusion: We believe that the anti-arthritic activity of GDBT is due to its modulatory effect on the expression of pro-inflammatory cytokine in the synovium. Our results contribute towards validation of the traditional use of GDBT in the treatment of RA and other inflammatory joint disorders.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (0)
참고문헌 신청이 논문의 저자 정보
이 논문과 함께 이용한 논문
白首烏의 명칭과 수확 시기 연구
이제현
,
권기태
대한한의학회지
2012
.03
뇌졸중 환자의 체간조절 능력과 동적균형 및 보행과의 상관관계
정은정
,
이종수
,
김성식
외 1명
대한한의학회지
2012
.03
팔체질 의학에 대한 논문 리뷰
이주호
,
김희주
,
신용섭
외 2명
대한한의학회지
2012
.03
보건소 건강증진 사업 중 한방육아교실의 운영과 효과에 관한 연구
박은성
,
문윤희
,
김양희
외 2명
대한한의학회지
2012
.03
접착식 간접구의 연기 밀도 및 유해가스 발생 확인 연구
김은정
,
김유종
,
황지후
외 4명
대한한의학회지
2012
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000273064