지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: This study was aimed to investigate the effectof Bojungikgitang-gagambang (BJIG) on longitudinal bone growth in rats.
Methods: The BJIG treated group (300 mg/kg) and the control group (vehicle) were administered orally twice daily for 4 days. To investigate the effects of BJIG we measured body weight gain. The bone growth effect was analyzed by measuring between fluorescent lines marked with tetracycline, which plays the role of fluorescent dye on the surface of the tibia. Tetracycline was intraperitoneally injected. The height of growth plates in the epiphyseal plate was measured. The expression of bone morphogenetic protein-2 (BMP-2) and insuline-like growth factor-1 (IGF-1) was investigated by immunohistochemistry.
Results: BJIG caused a significant acceleration of longitudinal bone growth of 349.7 ± 15.9 /day compared to control (319.8 ± 21.4 /day). The height of overall growth plate was not significantly more compared to the control, but the size of cells in the proliferative zone and hypertrophic zone were. In the immunohistochemistry, BMP-2 and IGF-1 were expressed markedly in the proliferative or hypertrophic zone, respectively.
Conclusions: BJIG stimulated the chondrocyte hypertrophy and chondrogenesis in the growth plate and directly increased the longitudinal tibia length of rats.
Methods: The BJIG treated group (300 mg/kg) and the control group (vehicle) were administered orally twice daily for 4 days. To investigate the effects of BJIG we measured body weight gain. The bone growth effect was analyzed by measuring between fluorescent lines marked with tetracycline, which plays the role of fluorescent dye on the surface of the tibia. Tetracycline was intraperitoneally injected. The height of growth plates in the epiphyseal plate was measured. The expression of bone morphogenetic protein-2 (BMP-2) and insuline-like growth factor-1 (IGF-1) was investigated by immunohistochemistry.
Results: BJIG caused a significant acceleration of longitudinal bone growth of 349.7 ± 15.9 /day compared to control (319.8 ± 21.4 /day). The height of overall growth plate was not significantly more compared to the control, but the size of cells in the proliferative zone and hypertrophic zone were. In the immunohistochemistry, BMP-2 and IGF-1 were expressed markedly in the proliferative or hypertrophic zone, respectively.
Conclusions: BJIG stimulated the chondrocyte hypertrophy and chondrogenesis in the growth plate and directly increased the longitudinal tibia length of rats.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Cohen P / 2007 / 2007 ISS Consensus Workshop participants. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: A summary of the growth hormone research society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology workshop / Journal of Clinical Endocrinology & Metabolism 93 (11) : 4210 ~ 4217
2. [학술지(정기간행물)] - Kelnar CJ / 2011 / Idiopathic short stature: Considerations from the clinic-the viewpoint of the paediatric endocrinologist / Hormone Research in Paediatrics 76 (3) : 35 ~ 37
3. [학술지(정기간행물)] - Wit JM / 2008 / Idiopathic short stature: Management and growth hormone treatment / Growth Hormone & IGF Research 18 (2) : 111 ~ 135
4. [학술지(정기간행물)] - Leem K / 2003 / Effects of jaoga-yukmiwon(R), a Korean herbal medicine, on chondrocyte proliferation and longitudinal bone growth in adolescent male rats / Phytotherapy Research 17 (9) : 1113 ~ 1116
5. [학술지(정기간행물)] - Mi-Yeon Kim / 2010 / The Herbal Formula HT042 Induces Longitudinal Bone Growth in Adolescent Female Rats / Journal of Medicinal Food 13 (6) : 1376 ~ 1384
2. [학술지(정기간행물)] - Kelnar CJ / 2011 / Idiopathic short stature: Considerations from the clinic-the viewpoint of the paediatric endocrinologist / Hormone Research in Paediatrics 76 (3) : 35 ~ 37
3. [학술지(정기간행물)] - Wit JM / 2008 / Idiopathic short stature: Management and growth hormone treatment / Growth Hormone & IGF Research 18 (2) : 111 ~ 135
4. [학술지(정기간행물)] - Leem K / 2003 / Effects of jaoga-yukmiwon(R), a Korean herbal medicine, on chondrocyte proliferation and longitudinal bone growth in adolescent male rats / Phytotherapy Research 17 (9) : 1113 ~ 1116
5. [학술지(정기간행물)] - Mi-Yeon Kim / 2010 / The Herbal Formula HT042 Induces Longitudinal Bone Growth in Adolescent Female Rats / Journal of Medicinal Food 13 (6) : 1376 ~ 1384
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UCI(KEPA) : I410-ECN-0101-2014-519-000272825