지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: There is a steady increase in the prevalence of obesity worldwide and obesity is often accompanied by inflammation. Although much emphasis has been placed on the adipose tissue inflammation in obesity, a study with herbal medicine is few. This study aimed to investigate the antidiabetic and anti-inflammatory effect of a complex herbal medicine (CHM) composed of Cornus officinalis, Dioscorea rhizoma, Aurantii fructus, and Mori Foliumon on obese type 2 diabetes mice.
Methods: Type 2 diabetes mellitus and obesity were induced by Surwit"s high fat, high sucrose diet for 8 weeks.
Mice were divided into ND (normal diet, n=10), HFD (high fat and high sucrose diet, n=10), CHM (high fat and high sucrose diet with complex herbal medicine, n=10) and Met (high fat and high sucrose diet with metformin, n=10) groups. The body weight, fructosamine and OGTT (oral glucose tolerance test) were measured. After 8 weeks the blood samples of all mice were taken from the heart, and lipid profiles were measured. Epididymal fat pad, histological size of the adipocyte tissue and liver weights were measured. Inflammatory markers such as leptin and adipocyte tissue macrophage were measured to evaluate the effect of CHM on adipocyte tissue inflammation.
Results: Compared with the HFD group, there was an improvement in OGTT and epididymal fat decreased in the CHM group. White adipocyte size and adipocyte tissue macrophage decreased in CHM group.
Conclusions: These results suggest that CHM has antidiabetic and anti-inflammatory effects in high fat, high sucrose diet induced obese mice.
Methods: Type 2 diabetes mellitus and obesity were induced by Surwit"s high fat, high sucrose diet for 8 weeks.
Mice were divided into ND (normal diet, n=10), HFD (high fat and high sucrose diet, n=10), CHM (high fat and high sucrose diet with complex herbal medicine, n=10) and Met (high fat and high sucrose diet with metformin, n=10) groups. The body weight, fructosamine and OGTT (oral glucose tolerance test) were measured. After 8 weeks the blood samples of all mice were taken from the heart, and lipid profiles were measured. Epididymal fat pad, histological size of the adipocyte tissue and liver weights were measured. Inflammatory markers such as leptin and adipocyte tissue macrophage were measured to evaluate the effect of CHM on adipocyte tissue inflammation.
Results: Compared with the HFD group, there was an improvement in OGTT and epididymal fat decreased in the CHM group. White adipocyte size and adipocyte tissue macrophage decreased in CHM group.
Conclusions: These results suggest that CHM has antidiabetic and anti-inflammatory effects in high fat, high sucrose diet induced obese mice.
목차
서론
연구방법
결과
고찰
결론
참고문헌
참고문헌 (36)
참고문헌 신청
1. [단행본] - Gardner D / 2007 / Greenspan's basic & clinical endocrinology / McGrawHill : 675 ~ 676
2. [학술지(정기간행물)] - Hotamisligil GS / 1993 / Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance / Science 259 (5091) : 87 ~ 91
3. [학술지(정기간행물)] - Weisberg SP / 2003 / Obesity is associated with macrophage accumulation in adipose tissue / Journal of Clinical Investigation 112 : 1796 ~ 1808
4. [학술지(정기간행물)] - Cancello R / 2006 / Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue / BJOG 113 (10) : 1141 ~ 1147
5. [학술지(정기간행물)] - Yamabe N / 2007 / Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats / Biological & Pharmaceutical Bulletin 30 (7) : 1289 ~ 1296
2. [학술지(정기간행물)] - Hotamisligil GS / 1993 / Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance / Science 259 (5091) : 87 ~ 91
3. [학술지(정기간행물)] - Weisberg SP / 2003 / Obesity is associated with macrophage accumulation in adipose tissue / Journal of Clinical Investigation 112 : 1796 ~ 1808
4. [학술지(정기간행물)] - Cancello R / 2006 / Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue / BJOG 113 (10) : 1141 ~ 1147
5. [학술지(정기간행물)] - Yamabe N / 2007 / Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats / Biological & Pharmaceutical Bulletin 30 (7) : 1289 ~ 1296
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UCI(KEPA) : I410-ECN-0101-2014-519-000272729