지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury.
Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed.
Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-α and IL-1β in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue.
Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.
Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed.
Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-α and IL-1β in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue.
Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.
목차
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결과
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감사의 말씀
참고문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Celli BR / 2004 / Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper / Eur Respir J 23 (6) : 932 ~ 946
2. [학술지(정기간행물)] - Kim DS / 2005 / Prevalence of chronic obstructive pulmonary disease in Korea - A population-based spirometry survey / AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 172 : 842 ~ 847
3. [인터넷자원] - Korea National Statistical Office / / Dajeon: Korea National Statistical Office
4. [인터넷자원] - World Health Report / / World Health Organization, Geneva
5. [학술지(정기간행물)] - Rabe KF / 2007 / Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary / Am J Respir Crit Care Med 176 (6) : 532 ~ 555
2. [학술지(정기간행물)] - Kim DS / 2005 / Prevalence of chronic obstructive pulmonary disease in Korea - A population-based spirometry survey / AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 172 : 842 ~ 847
3. [인터넷자원] - Korea National Statistical Office / / Dajeon: Korea National Statistical Office
4. [인터넷자원] - World Health Report / / World Health Organization, Geneva
5. [학술지(정기간행물)] - Rabe KF / 2007 / Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary / Am J Respir Crit Care Med 176 (6) : 532 ~ 555
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UCI(KEPA) : I410-ECN-0101-2014-519-000281104