지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study was aimed to investigate the effects of Galhwahyejung-tang (GHT) on alcohol-induced oxidative stress in rat model.
Methods: Twenty SD rats were orally administrated with 40% ethanol (mL/kg) combined with GHT (50, 100, 200mg/kg) or distilled water for 2 weeks. Biochemistry in blood, malondialdehyde (MDA), total reactive oxygen species (ROS), and total antioxidant capacity (TAC) in serum, liver, brain, and kidney were determined.
Results: GHT treatment significantly ameliorated the alcohol-induced alteration of hepatic enzyme; especially AST and ALT. GHT treatment also ameliorated the increase of MDA in liver, ROS level in serum and brain. GHT treatment reduced the depletion of antioxidant capacity in serum and brain.
Conclusion: These results that GHT has antioxidant properties explaining the relevance of clinical application and its partial mechanisms of GHT.
Methods: Twenty SD rats were orally administrated with 40% ethanol (mL/kg) combined with GHT (50, 100, 200mg/kg) or distilled water for 2 weeks. Biochemistry in blood, malondialdehyde (MDA), total reactive oxygen species (ROS), and total antioxidant capacity (TAC) in serum, liver, brain, and kidney were determined.
Results: GHT treatment significantly ameliorated the alcohol-induced alteration of hepatic enzyme; especially AST and ALT. GHT treatment also ameliorated the increase of MDA in liver, ROS level in serum and brain. GHT treatment reduced the depletion of antioxidant capacity in serum and brain.
Conclusion: These results that GHT has antioxidant properties explaining the relevance of clinical application and its partial mechanisms of GHT.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgement
References
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Graham K / 2007 / Does the association between alcohol consumption and depression depend on how they are measured? / Alcohol Clin Exp Res 31 : 78 ~ 88
2. [학술지(정기간행물)] - 채희복 / 2009 / 알코올 간질환 / 대한소화기학회지 53 (5) : 275 ~ 282
3. [학술지(정기간행물)] - 정우진 / 2006 / 주종별 알코올의 사회경제적 비용 추계 : 술 주종과 사회경제적 비용의 연관성 연구 / 대한보건연구 32 (1) : 1 ~ 8
4. [학술지(정기간행물)] - Meier P / 2008 / Age, alcohol metabolism and liver disease / Curr Opin Clin Nutr Metab Care 11 (1) : 21 ~ 26
5. [학술지(정기간행물)] - Lieber CS / 2005 / Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years / Rocz Akad Med Bialymst 50 : 7 ~ 20
2. [학술지(정기간행물)] - 채희복 / 2009 / 알코올 간질환 / 대한소화기학회지 53 (5) : 275 ~ 282
3. [학술지(정기간행물)] - 정우진 / 2006 / 주종별 알코올의 사회경제적 비용 추계 : 술 주종과 사회경제적 비용의 연관성 연구 / 대한보건연구 32 (1) : 1 ~ 8
4. [학술지(정기간행물)] - Meier P / 2008 / Age, alcohol metabolism and liver disease / Curr Opin Clin Nutr Metab Care 11 (1) : 21 ~ 26
5. [학술지(정기간행물)] - Lieber CS / 2005 / Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years / Rocz Akad Med Bialymst 50 : 7 ~ 20
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UCI(KEPA) : I410-ECN-0101-2014-519-000285288