지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : To clarify the effects of Jungri-tang Gamibang on accelerating small intestinal movement induced by the stimulation of cholinergic neurotransmission.
Methods : 500, 250 and 125mg Jungri-Tang Gamibang or 20mg domperidone were dissolved or suspended in distilled water and orally pretreated on the carbachol-accelerated small intestinal transit mice once a day for 7 days at a volume of 10ml/kg (of body weight) using a Zonde needle attached to 1 ml syringes containing test drugs.
Result : Significantly (p<0.01) increase of % regions of activated charcoal transit in the small intestine was detected in carbachol control compared to that of intact control. However, significant (p<0.01) decreases of % regions of activated charcoal transit were dose-dependently observed in all Jungri-Tang Gamibang extracts or domperidonepretreated groups.
Conclusions : it was concluded that Jungri-tang Gamibang enhancement in the normal intestinal motility and normalization in the accelerated intestinal motility might interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilization of calcium ions required for smooth muscle contraction non-specifically.
Methods : 500, 250 and 125mg Jungri-Tang Gamibang or 20mg domperidone were dissolved or suspended in distilled water and orally pretreated on the carbachol-accelerated small intestinal transit mice once a day for 7 days at a volume of 10ml/kg (of body weight) using a Zonde needle attached to 1 ml syringes containing test drugs.
Result : Significantly (p<0.01) increase of % regions of activated charcoal transit in the small intestine was detected in carbachol control compared to that of intact control. However, significant (p<0.01) decreases of % regions of activated charcoal transit were dose-dependently observed in all Jungri-Tang Gamibang extracts or domperidonepretreated groups.
Conclusions : it was concluded that Jungri-tang Gamibang enhancement in the normal intestinal motility and normalization in the accelerated intestinal motility might interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilization of calcium ions required for smooth muscle contraction non-specifically.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Costall B / 1983 / Field stimulationinduced responses of circular smooth muscle from guinea-pig stomach. Characterisation of the receptor mechanisms involved / Naunyn Schmiedebergs Arch Pharmacol 323 : 155 ~ 161
2. [학술지(정기간행물)] - Sahyoun HA / 1982 / Catecholamines act as alpha 2-adrenoceptors to cause contraction of circular smooth muscle of guineapig stomach / J. Pharm Pharmacol 34 : 381 ~ 385
3. [학술지(정기간행물)] - Hay AM / 1979 / Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine / Gastroenterology 76 : 492 ~ 496
4. [학술지(정기간행물)] - Van Nueten JM / 1984 / Studies on the role of dopamine and dopamine blockers in gastroduodenal motility / Scand J. Gastroenterol Suppl 96 : 89 ~ 99
5. [학술지(정기간행물)] - Hayakawa T / 1999 / Pharmacological studies of the effect of Daikenchuto on spontaneous contraction of isolated rabbit jejunum / J. Smooth Muscle Res 35 : 55 ~ 62
2. [학술지(정기간행물)] - Sahyoun HA / 1982 / Catecholamines act as alpha 2-adrenoceptors to cause contraction of circular smooth muscle of guineapig stomach / J. Pharm Pharmacol 34 : 381 ~ 385
3. [학술지(정기간행물)] - Hay AM / 1979 / Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine / Gastroenterology 76 : 492 ~ 496
4. [학술지(정기간행물)] - Van Nueten JM / 1984 / Studies on the role of dopamine and dopamine blockers in gastroduodenal motility / Scand J. Gastroenterol Suppl 96 : 89 ~ 99
5. [학술지(정기간행물)] - Hayakawa T / 1999 / Pharmacological studies of the effect of Daikenchuto on spontaneous contraction of isolated rabbit jejunum / J. Smooth Muscle Res 35 : 55 ~ 62
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UCI(KEPA) : I410-ECN-0101-2014-519-000282136