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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : Formulas for treatment of yin or yang deficiency conditions have been commonly used in traditional Korean medicine. The aim of this study is to examine the possible inhibitory effects of yin- or yang-tonifying formulas on in vivo anti-platelet activity and in vivo anti-thrombotic activity.
Methods : We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane B2 immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice.
Results : 3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p<0.01). Also, through in vivo study, the antithrombotic activities of Igyeong-tang, Gamisipjeondaebo-tang, and Gamisoyo-san-treated groups, with recovery rate of 60, 50, and 45.45%, respectively, were observed to be higher than those of the control group (saline, 36.8%) in mouse acute thrombosis.
Conclusion : These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.
Methods : We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane B2 immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice.
Results : 3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p<0.01). Also, through in vivo study, the antithrombotic activities of Igyeong-tang, Gamisipjeondaebo-tang, and Gamisoyo-san-treated groups, with recovery rate of 60, 50, and 45.45%, respectively, were observed to be higher than those of the control group (saline, 36.8%) in mouse acute thrombosis.
Conclusion : These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
참고문헌 (24)
참고문헌 신청
1. [단행본] - Song TW / 2007 / Introduction to Traditional Korean Medicine / Korea Institute of Oriental Medicine
2. [단행본] - Yamada H / 2005 / Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications / CRC press : 1 ~ 6
3. [단행본] - Hosoya E / 1988 / Scientific evaluation of Kampo prescriptions using modern technology. in Recent advances in the pharmacology of Kampo (Japanese Herbal) Medicines / Excerpta Medica : 17 ~ 29
4. [학술지(정기간행물)] - Seki K / 2005 / An attempt to integrate western and Chinese medicine: rationale for applying Chinese medicine as chronotherapy against cancer / Biomed Pharmacother 59 : S132 ~ S140
5. [학술지(정기간행물)] - Ko KM / 2004 / Pharmacological basis of ‘Yang-invigoration’ in Chinese medicine / Trends Pharmacol Sci 25 : 3 ~ 6
2. [단행본] - Yamada H / 2005 / Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications / CRC press : 1 ~ 6
3. [단행본] - Hosoya E / 1988 / Scientific evaluation of Kampo prescriptions using modern technology. in Recent advances in the pharmacology of Kampo (Japanese Herbal) Medicines / Excerpta Medica : 17 ~ 29
4. [학술지(정기간행물)] - Seki K / 2005 / An attempt to integrate western and Chinese medicine: rationale for applying Chinese medicine as chronotherapy against cancer / Biomed Pharmacother 59 : S132 ~ S140
5. [학술지(정기간행물)] - Ko KM / 2004 / Pharmacological basis of ‘Yang-invigoration’ in Chinese medicine / Trends Pharmacol Sci 25 : 3 ~ 6
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UCI(KEPA) : I410-ECN-0101-2014-519-000282121