지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 80 - 86 (7page)
이용수
초록· 키워드
오류제보하기
Korean red ginseng has been shown to possess a variety of biological activities. However, little is known about antiviral activity of ginsenosides of Korean red ginseng. Here, we investigated the protective effect by oral administration of various ginsenosides on the lethal infection of haemagglutinating virus of Japan (HVJ) in mice. In a lethal infection model in which almost all mice infected with HVJ died within 15 days, the mice were administered orally (per os) with 1 mg/mouse of dammarane-type (ginsenoside-Rb1, -Rb2, -Rd, -Re, and -Rg2) or oleanolic acid-type (ginsenoside-Ro) ginsenosides 3, 2, and 1 d before virus infection. Ginsenoside- Rb2 showed the highest protective activity, although other dammarane-type and oleanolic acid-type ginsenosides also induced a significant protection against HVJ. However, neither the consecutive administration with a lower dosage (300 mg/mouse) nor the single administration of ginsenoside-Rb2 (1 mg/mouse) was active. In comparison of the protective activity between ginsenoside-Rb2 and its two hydrolytic products [20(S)- and 20(R)-ginsenoside-Rg3], 20(S)-ginsenoside-Rg3, but not 20(R)-ginsenoside-Rg3, elicited a partial protection against HVJ. The protective effect of ginsenoside-Rb2 and 20(S)-ginsenoside-Rg3 on HVJ infection was confirmed by the reduction of virus titers in the lungs of HVJ-infected mice. These results suggest that ginsenoside-Rb2 is the most effective among ginsenosides from red ginseng to prevent the lethal infection of HVJ, so that this ginsenoside is a promising candidate as a mucosal immunoadjuvant to enhance antiviral activity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Song X / 2009 / Adjuvant activities of saponins from traditional Chinese medicinal herbs / Vaccine 27 : 4883 ~ 4890
2. [학술지(정기간행물)] - Sun HX / 2009 / Advances in saponin-based adjuvants / Vaccine 27 : 1787 ~ 1796
3. [학술지(정기간행물)] - Rempel R / 2004 / Application of Quillaja saponaria extracts as oral adjuvants for plant-made vaccines / Expert Opin Biol Ther 4 : 947 ~ 958
4. [학술지(정기간행물)] - Pickering RJ / 2006 / Crude saponins improve the immune response to an oral plant-made measles vaccine / Vaccine 24 : 144 ~ 150
5. [학술지(정기간행물)] - Park D / 2011 / Immunopotentiation and antitumor effects of a ginsenoside Rg3-fortified red ginseng preparation in mice bearing H460 lung cancer cells / Environ Toxicol Pharmacol 31 : 397 ~ 405
2. [학술지(정기간행물)] - Sun HX / 2009 / Advances in saponin-based adjuvants / Vaccine 27 : 1787 ~ 1796
3. [학술지(정기간행물)] - Rempel R / 2004 / Application of Quillaja saponaria extracts as oral adjuvants for plant-made vaccines / Expert Opin Biol Ther 4 : 947 ~ 958
4. [학술지(정기간행물)] - Pickering RJ / 2006 / Crude saponins improve the immune response to an oral plant-made measles vaccine / Vaccine 24 : 144 ~ 150
5. [학술지(정기간행물)] - Park D / 2011 / Immunopotentiation and antitumor effects of a ginsenoside Rg3-fortified red ginseng preparation in mice bearing H460 lung cancer cells / Environ Toxicol Pharmacol 31 : 397 ~ 405
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-524-000316429