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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 8 - 29 (22page)
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초록· 키워드
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Ginseng is one of the most widely used herbal medicines in human. Central nervous system (CNS) diseases are most widely investigated diseases among all others in respect to the ginseng’s therapeutic effects. These include Alzheimer’s disease, Parkinson’s disease, cerebral ischemia, depression, and many other neurological disorders including neurodevelopmental disorders. Not only the various types of diseases but also the diverse array of target pathways or molecules ginseng exerts its effect on. These range, for example, from neuroprotection to the regulation of synaptic plasticity and from regulation of neuroinflammatory processes to the regulation of neurotransmitter release, too many to mention. In general, ginseng and even a single compound of ginsenoside produce its effects on multiple sites of action, which make it an ideal candidate to develop multi-target drugs. This is most important in CNS diseases where multiple of etiological and pathological targets working together to regulate the final pathophysiology of diseases. In this review, we tried to provide comprehensive information on the pharmacological and therapeutic effects of ginseng and ginsenosides on neurodegenerative and other neurological diseases. Side by side comparison of the therapeutic effects in various neurological disorders may widen our understanding of the therapeutic potential of ginseng in CNS diseases and the possibility to develop not only symptomatic drugs but also disease modifying reagents based on ginseng.
목차
INTRODUCTION
ALZHEIMER’S DISEASE
PARKINSON’S DISEASE
OTHER NEURODEGENERATIVE DISORDERS
CEREBRAL ISCHEMIA
DEPRESSION
ANXIETY
ADDICTION
OTHER PSYCHIATRIC DISORDERS
NEURODEVELOPMENTAL DISORDERS
CONCLUSION
REFERENCES
참고문헌 (163)
참고문헌 신청
1. [학술지(정기간행물)] - Lu G / 2008 / Differentiation of Asian ginseng, American ginseng and Notoginseng by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy / J Mol Struct 883-884 : 91 ~ 98
2. [학술지(정기간행물)] - Tachikawa E / 1999 / Effects of ginseng saponins on responses induced by various receptor stimuli / Eur J Pharmacol 369 : 23 ~ 32
3. [학술지(정기간행물)] - Sung H / 2009 / Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients / Clin Vaccine Immunol 16 : 1127 ~ 1131
4. [학술지(정기간행물)] - Radad K / 2011 / Ginsenosides and their CNS targets / CNS Neurosci Ther 17 : 761 ~ 768
5. [학술지(정기간행물)] - Jesky R / 2011 / Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines / Phytother Res 25 : 1105 ~ 1118
2. [학술지(정기간행물)] - Tachikawa E / 1999 / Effects of ginseng saponins on responses induced by various receptor stimuli / Eur J Pharmacol 369 : 23 ~ 32
3. [학술지(정기간행물)] - Sung H / 2009 / Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients / Clin Vaccine Immunol 16 : 1127 ~ 1131
4. [학술지(정기간행물)] - Radad K / 2011 / Ginsenosides and their CNS targets / CNS Neurosci Ther 17 : 761 ~ 768
5. [학술지(정기간행물)] - Jesky R / 2011 / Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines / Phytother Res 25 : 1105 ~ 1118
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