지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 118 - 128 (11page)
이용수
초록· 키워드
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Objective: The aim of this study was to investigate and compare the in vivo effects of prostaglandin E2 (PGE2) administered by different methods on orthodontic tooth movement and bone metabolism macroscopically, histopatologically, and biochemically. Methods: Forty-five young adult New Zealand rabbits were randomly divided into 3 experimental groups (n = 10/group), 1 positive control group (n = 10), and 1 negative control group (n = 5). The experimental rabbits were fitted with springs exerting 20-g reciprocal force on the maxillary incisors and PGE2 (10 μg/mL) was administered by the intravenous, submucosal, or intraligamentous route after appliance insertion and on days 1, 3, 7, and 14 thereafter. All rabbits were sacrificed on day 21 and their premaxillae were resected for histologic evaluation. Results: Tooth movement was observed in the experimental and positive control groups, but the intraligamentous PGE2 group had the highest values of all analyzed parameters, including serum calcium and phosphorus levels and osteoclastic and osteoblastic populations (p < 0.001). Conclusions: Submucosal and intraligamentous PGE2 administration significantly increases orthodontic tooth movement and bone metabolism, but the intraligamentous route seems to be more effective.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (31)
참고문헌 신청
van de Velde JP / 1988 / Histologic reactions in gingival and alveolar tissues during tooth movement in rabbits / Eur J Orthod 10:296~308
Persson M / 2005 / A 100th anniversary: Sandstedt’s experiments on tissue changes during tooth movement / J Orthod 32:27~28
Baumrind S / 1970 / Rate changes in cell repli cation and protein synthesis in the periodontal liga ment incident to tooth movement / Am J Orthod 57:109~131
Lilja E / 1983 / Histochemistry of enzymes associated with tissue degradation incident to orthodontic tooth movement / Am J Orthod 83:62~75
Yamasaki K / 1984 / Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement / Am J Orthod 85:508~518
Persson M / 2005 / A 100th anniversary: Sandstedt’s experiments on tissue changes during tooth movement / J Orthod 32:27~28
Baumrind S / 1970 / Rate changes in cell repli cation and protein synthesis in the periodontal liga ment incident to tooth movement / Am J Orthod 57:109~131
Lilja E / 1983 / Histochemistry of enzymes associated with tissue degradation incident to orthodontic tooth movement / Am J Orthod 83:62~75
Yamasaki K / 1984 / Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement / Am J Orthod 85:508~518
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UCI(KEPA) : I410-ECN-0101-2014-515-000447591