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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 155 - 163 (9page)
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초록· 키워드
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Objectives：A number of studies have shown dysregulation of the hypothalamus-pituitary-adrenal axis in alcoholics. The aim of the present study was to determine whether there are differences in salivary cortisol responses to a psychological stressor between nonalcoholic offspring from families with a history of alcoholism and those without a family history of alcoholism in Korea.
Methods：We studied 45 healthy social drinkers, who were medical students aged≥18 years. The participants completed a baseline assessment and, salivary cortisol levels were obtained. All subjects were exposed to almost 15 minutes of stress. Immediately following completion of the stress exposure, four additional salivary specimens were obtained for cortisol levels at 15 minute intervals. The subjects were divided into two groups those who reported a history of alcoholism in either parent(FHP, n=9) and those who reported no alcoholism in their family for three generations(FHN, n=30).
Results：A significant difference in salivary cortisol by family history group(p＜.001), and by time was discovered (p=.005) with a repeated-measures ANOVA. Basal salivary cortisol levels in FHP subjects were significantly higher than those in FHN subjects(p=.003). After stress exposure, salivary cortisol levels decreased significantly over time in the FHN group, whereas they did not in the FHP group.
Conclusion：FHP subjects had higher baseline salivary cortisol concentrations than those of FHN subjects and maintained the levels after stress. This finding suggests that social drinkers with a history of alcoholism in a parent have increased vulnerability to stress and difficulty coping with stress effectively.
Methods：We studied 45 healthy social drinkers, who were medical students aged≥18 years. The participants completed a baseline assessment and, salivary cortisol levels were obtained. All subjects were exposed to almost 15 minutes of stress. Immediately following completion of the stress exposure, four additional salivary specimens were obtained for cortisol levels at 15 minute intervals. The subjects were divided into two groups those who reported a history of alcoholism in either parent(FHP, n=9) and those who reported no alcoholism in their family for three generations(FHN, n=30).
Results：A significant difference in salivary cortisol by family history group(p＜.001), and by time was discovered (p=.005) with a repeated-measures ANOVA. Basal salivary cortisol levels in FHP subjects were significantly higher than those in FHN subjects(p=.003). After stress exposure, salivary cortisol levels decreased significantly over time in the FHN group, whereas they did not in the FHP group.
Conclusion：FHP subjects had higher baseline salivary cortisol concentrations than those of FHN subjects and maintained the levels after stress. This finding suggests that social drinkers with a history of alcoholism in a parent have increased vulnerability to stress and difficulty coping with stress effectively.
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서론
대상 및 방법
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참고문헌
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Miller DB / 2002 / Neuroendocrine aspects of the response to stress / Metabolism 51 : 5 ~ 10
2. [학술지(정기간행물)] - McEwen BS / 1998 / Protective and damaging effects of stress mediators / N Engl J Med 338 : 171 ~ 179
3. [학술지(정기간행물)] - Tsigos C / 2002 / Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress / J Psychosom Res 53 : 865 ~ 871
4. [학술지(정기간행물)] - Lee AL / 2002 / Stress and depression: possible links to neuron death in the hippocampus / Bipolar Disord 4 : 117 ~ 128
5. [학술지(정기간행물)] - Sapolsky RM / 2000 / Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders / Arch Gen Psychiatr 57 : 925 ~ 935
2. [학술지(정기간행물)] - McEwen BS / 1998 / Protective and damaging effects of stress mediators / N Engl J Med 338 : 171 ~ 179
3. [학술지(정기간행물)] - Tsigos C / 2002 / Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress / J Psychosom Res 53 : 865 ~ 871
4. [학술지(정기간행물)] - Lee AL / 2002 / Stress and depression: possible links to neuron death in the hippocampus / Bipolar Disord 4 : 117 ~ 128
5. [학술지(정기간행물)] - Sapolsky RM / 2000 / Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders / Arch Gen Psychiatr 57 : 925 ~ 935
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UCI(KEPA) : I410-ECN-0101-2014-513-000468498