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논문 기본 정보

자료유형
학술저널
저자정보
Hee-Bong Pyun (Yonsei University) Minji Kim (Yonsei University) Jieun Park (Yonsei University) Yasuo Sakai (Jellice) Noriaki Numata (Jellice) Jin-Yeong Shin (Amorepacific Corporation R&D Center) Hyun-Jung Shin (Amorepacific Corporation R&D Center) Do-Un Kim (Newtree) Jae-Kwan Hwang (Yonsei University)
저널정보
한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.17 No.4
발행연도
2012.12
수록면
245 - 253 (9page)

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초록· 키워드

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Collagen tripeptide (CTP) is a functional food material with several biological effects such as improving dry skin and wound and bone fracture healing. This study focused on the anti-photoaging effects of CTP on a hairless mouse model. To evaluate the effects of CTP on UVB-induced skin wrinkle formation in vivo, the hairless mice were exposed to UVB radiation with oral administration of CTP for 14 weeks. Compared with the untreated UVB control group, mice treated with CTP showed significantly reduced wrinkle formation, skin thickening, and transepidermal water loss (TEWL). Skin hydration and hydroxyproline were increased in the CTP-treated group. Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and-9 expressions. Oral administration of CTP increased skin elasticity and decreased abnormal elastic fiber formation. Erythema was also decreased in the CTP-treated group. Taken together, these results strongly suggest that CTP has potential as an anti-photoaging agent.

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Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2014-511-000596528