지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 279 - 288 (10page)
이용수
초록· 키워드
오류제보하기
Rats were administered zearalenone (ZEA) via gavage at dosages of 0, 1, 5, and 30 mg/kg for 36 days. On treatment day 8, inactivated porcine parvovirus vaccine (Vac) was injected intraperitoneally. Antibody production against porcine parvovirus was then measured as a function of ZEA treatment. Compared to the vaccine alone, ZEA treatment, with or without Vac, decreased the serum level of IgG. The level of IgM decreased in all ZEA groups at day 22, but the decrease was sustained only in the medium-dose ZEA group at day 36. The level of IgA was unchanged in the Vac only and ZEA groups at day 22, but was decreased in the 5 mg/kg ZEA plus Vac group compared to the Vac only group at day 36. The level of IgE was decreased by all doses of ZEA at day 22, but was unaffected in ZEA plus Vac groups compared to the Vac only group. The levels of IL-1 in the thymus and spleen; INF-γ in serum; IL-2, IL-6, and IL-10 in the thymus; and IL-10 and IFN-γ in the spleen decreased after ZEA administration. Furthermore, the levels of IL-1β in the spleen and mesenteric lymph node, IL-1β in the thymus, IL-2 in the thymus and spleen, IL-6 in the thymus, IL-10 and IFN-γ in the spleen, and GM-CSF and TNF-α in the thymus decreased after vaccination in rats exposed to ZEA. In conclusion, these results suggest that ZEA exposure via drinking water can cause an immunosuppressive effect by decreasing immunoglobulins in serum and cytokines in lymphoid organs.
목차
INTRODUCTION
MATERIALS AND METHOD
RESULTS
DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
Abbès, S. / 2006 / The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice / Toxicon 47:567~574
Abbès, S. / 2006 / Preventive role of phyllosilicate clay on the Immunological and Biochemical toxicity of zearalenone in Balb/c mice / Int. Immunopharmacol 6:1251~1258
Ahmed, T. / 1992 / Peripheral blood stem cell mobilization by cytokines / J. Clin. Apher 7:129~131
Atkinson, H.A / 1984 / Inhibitory effect of deoxynivalenol,3-acetyldeoxynivalenol and zearalenone on inductionof rat and human lymphocyte proliferation / Toxicol. Lett 23:215~221
Ben Salah-Abbès, J. / 2008 / Zearalenone induces immunotoxicity in mice: possible protective effects of radish extract (Raphanus sativus) / J. Pharm. Pharmacol 60:761~770
Abbès, S. / 2006 / Preventive role of phyllosilicate clay on the Immunological and Biochemical toxicity of zearalenone in Balb/c mice / Int. Immunopharmacol 6:1251~1258
Ahmed, T. / 1992 / Peripheral blood stem cell mobilization by cytokines / J. Clin. Apher 7:129~131
Atkinson, H.A / 1984 / Inhibitory effect of deoxynivalenol,3-acetyldeoxynivalenol and zearalenone on inductionof rat and human lymphocyte proliferation / Toxicol. Lett 23:215~221
Ben Salah-Abbès, J. / 2008 / Zearalenone induces immunotoxicity in mice: possible protective effects of radish extract (Raphanus sativus) / J. Pharm. Pharmacol 60:761~770
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UCI(KEPA) : I410-ECN-0101-2014-513-000614665