지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 255 - 262 (8page)
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초록· 키워드
오류제보하기
Inflammation is the immune system’s response to infection and injury-related disorders, and is related to pro-inflammatory factors (NO, PGE<sub>2</sub>, cytokines, etc.) produced by inflammatory cells. Atopic dermatitis (AD) is a representative inflammatory skin disease that is characterized by increasing serum levels of inflammatory chemokines, including macrophage-derived chemokine (MDC). Carpinus tschonoskii is a member of the genus Carpinus. We investigated the anti-inflammatory activity of C. tschonoskii by studying the effects of various solvent fractions prepared from its leaves on inflammatory mediators in HaCaT and RAW264.7 cells. We found that the chloroform fraction of C. tschonoskii inhibited MDC at both the protein and mRNA levels in HaCaT cells, acting via the inhibition of STAT1 in the IFN-γ signaling pathway. In addition, the chloroform fraction significantly suppressed the expression of inflammatory factors induced by lipopolysaccharide stimulation, except COX-2 and TNF-α. These results suggest that the chloroform fraction of C. tschonoskii leaves may include a component with potential anti-inflammatory activity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Coleman, J. W. / 2001 / Nitric oxide in immunity and inflammation. Int / Immunopharmacol 1:1397~1406
Dereje Damte / 2011 / Anti-inflammatory Activity of Dichloromethane Extract of Auricularia auricula-judae in RAW264.7 Cells / 한국독성학회지 27(1):11~14
Duffield, J. S. / 2003 / The inflammatory macrophage: a story of Jekyll and Hyde / Clin. Sci 104:27~38
Gough, D. J. / 2008 / IFNgamma signaling-does it mean JAK-STAT? / Cytokine Growth Factor Rev 19:383~394
Hammer, K. D. / 2010 / Identification of JAK-STAT pathways as important for the antiinflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages / Phytochemistry 71:716~725
Dereje Damte / 2011 / Anti-inflammatory Activity of Dichloromethane Extract of Auricularia auricula-judae in RAW264.7 Cells / 한국독성학회지 27(1):11~14
Duffield, J. S. / 2003 / The inflammatory macrophage: a story of Jekyll and Hyde / Clin. Sci 104:27~38
Gough, D. J. / 2008 / IFNgamma signaling-does it mean JAK-STAT? / Cytokine Growth Factor Rev 19:383~394
Hammer, K. D. / 2010 / Identification of JAK-STAT pathways as important for the antiinflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages / Phytochemistry 71:716~725
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UCI(KEPA) : I410-ECN-0101-2014-513-000614630