지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 235 - 240 (6page)
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초록· 키워드
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<sup>99m</sup>Tc tricarbonyl glycine monomers, trimers, and pentamers were synthesized and evaluated for their radiolabeling and in vivo distribution characteristics. We synthesized a <sup>99m</sup>Tc-tricarbonyl precursor with a low oxidation state (I). <sup>99m</sup>Tc(CO)<SUB>3</SUB>(H<SUB>2</SUB>O)<SUB>3</SUB> <SUP>+</SUP> was then made to react with monomeric and oligomeric glycine for the development of bifunctional chelating sequences for biomolecules. Labeling yields of <sup>99m</sup>Tc-tricarbonyl glycine monomers and oligomers were checked by high-performance liquid chromatography. The labeling yields of <sup>99m</sup>Tc-tricarbonyl glycine and glycine oligomers were more than 95%. We evaluated the characteristics of <sup>99m</sup>Tc-tricarbonyl glycine oligomers by carrying out a lipophilicity test and an imaging study. The octanol-water partition coefficient of <sup>99m</sup>Tc tricarbonyl glycine oligomers indicated hydrophilic properties. Single-photon emission computed tomography imaging of <sup>99m</sup>Tc-tricarbonyl glycine oligomers showed rapid renal excretion through the kidneys with a low uptake in the liver, especially of <sup>99m</sup>Tc tricarbonyl triglycine. Furthermore, we verified that the addition of triglycine to prototype biomolecules (AGRGDS and RRPYIL) results in the improvement of radiolabeling yield. From these results, we conclude that triglycine has good characteristics for use as a bifunctional chelating sequence for a <sup>99m</sup>Tc-tricarbonyl- based biomolecular imaging probe.
목차
INTRODUCTION
MATERINALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2014-513-000614605