지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 225 - 233 (9page)
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초록· 키워드
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The present study was carried out to examine the toxicity and target organs of oral cholera vaccine (OCV) after repeated oral administration in Sprague-Dawley rats for 6 weeks (3 administrations, once every 2 weeks). OCV is an inactivated oral cholera vaccine that contains Vibrio cholerae and confers protection against cholera caused by V. cholera serogroups O1 (Inaba and Ogawa serotypes) and O139 (strain 4260B). The animals were orally administered either OCV placebo (negative control) or OCV at a dose equivalent to 240 times the anticipated human dose. Throughout the administration period, no significant change was detected in clinical signs, body weight, food or water consumption, urinalysis results, hematological and clinical biochemistry test results, organ weights, necropsy, or histopathological examination results. Minor changes were found in hematological and clinical biochemistry tests; however, these changes were within normal ranges. The above results suggest that oral administration of OCV in rats did not induce any toxicologically meaningful changes, and the target organs could not be determined. This study was conducted in accordance with the guidelines established by Good Laboratory Practice (2009-183, KFDA, December 22, 2009) and the OECD Principles of Good Laboratory Practice (1997).
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
Clemens, J. D. / 2011 / Vaccines in the time of cholera / Proc. Natl. Acad. Sci. U.S.A 108:8529~8530
Deen, J. L. / 2008 / The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa / PLoS Neglected Trop. Dis 2:173
Frerichs, R. R. / 2012 / Nepalese origin of cholera epidemic in Haiti / Clin. Microbiol. Infect 18:158~163
Greaves, P. / 2000 / Histopathology of preclinical toxicity studies: Interpretation and relevance in drug evaluation / Elsevier :1~892
Zhong-Ze Han / 2010 / Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies / Laboratory Animal Research 26(2):153~164
Deen, J. L. / 2008 / The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa / PLoS Neglected Trop. Dis 2:173
Frerichs, R. R. / 2012 / Nepalese origin of cholera epidemic in Haiti / Clin. Microbiol. Infect 18:158~163
Greaves, P. / 2000 / Histopathology of preclinical toxicity studies: Interpretation and relevance in drug evaluation / Elsevier :1~892
Zhong-Ze Han / 2010 / Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies / Laboratory Animal Research 26(2):153~164
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UCI(KEPA) : I410-ECN-0101-2014-513-000614594