지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 217 - 224 (8page)
이용수
초록· 키워드
오류제보하기
In recent decades, titanium dioxide (TiO<sub>2</sub>) nanoparticles have been used in various applications, including paints, coatings, and food. However, data are lacking on the toxicological aspects associated with their use. The aim of this study was to assess the inhalation toxicity of TiO<sub>2</sub> nanoparticles in rats by using inhalation exposure. Male Wistar rats were exposed to TiO<sub>2</sub> nanoparticles for 2 weeks (6 hr/day, 5 days/week) at a mean mass concentration of 11.39 ± 0.31 mg/㎥. We performed time-course necropsies at 1, 7, and 15 days after exposure. Lung inflammation and injury were assessed on the basis of the total and individual cell counts in bronchoalveolar lavage fluid (BALF), and by biochemical assays, including an assay for lactate dehydrogenase (LDH). Furthermore, histopathological examination was performed to investigate the lungs and nasal cavity of rats. There were no statistically significant changes in the number of BALF cells, results of biochemical assays of BALF and serum, and results of cytokine analysis. However, we did observe histopathological changes in the nasal cavity tissue. Lesions were observed at post-exposure days 1 and 7, which resolved at post-exposure day 15. We also calculated the actual amounts of TiO<sub>2</sub> nanoparticles inhaled by the rats. The results showed that the degree of toxicity induced by TiO<sub>2</sub> nanoparticles correlated with the delivered quantities. In particular, exposure to small particles with a size of approximately 20 nm resulted in toxicity, even if the total particle number was relatively low.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Alexander, D. J. / 2008 / Association of inhalation toxicologists (AIT) working party recommendation for standard delivered dose calculation and expression in non-clinical aerosol inhalation toxicology studies with pharmaceuticals / Inhal. Toxicol 20:1179~1189
Baan, R. A. / 2007 / Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: Recent evaluations by an iarc monographs working group / Inhal. Toxicol 19(1):213~228
Bermudez, E. / 2002 / Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles / Toxicol. Sci 70:86~97
Bermudez, E. / 2004 / Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles / Toxicol. Sci 77:347~357
최원용 / 200401 / Linear correlation between inactivation of E-coli and OH radical concentration in TiO2 photocatalytic disinfection / WATER RESEARCH 38(4):1069~1077
Baan, R. A. / 2007 / Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: Recent evaluations by an iarc monographs working group / Inhal. Toxicol 19(1):213~228
Bermudez, E. / 2002 / Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles / Toxicol. Sci 70:86~97
Bermudez, E. / 2004 / Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles / Toxicol. Sci 77:347~357
최원용 / 200401 / Linear correlation between inactivation of E-coli and OH radical concentration in TiO2 photocatalytic disinfection / WATER RESEARCH 38(4):1069~1077
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UCI(KEPA) : I410-ECN-0101-2014-513-000614589