지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 377 - 383 (7page)
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초록· 키워드
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Recent genome-wide association studies (GWAS) have identified a number of common variants associated with blood pressure homeostasis and hypertension in population. In the previous study, single nucleotide polymorphisms (SNPs) in the SLC4A4 gene have been reported to be associated with hypertension in Han Chinese population. We aimed to confirm whether the genetic variation of SLC4A4 gene influence the susceptibility to blood pressure and hypertension in Korean population. We genotyped variants in or near SLC4A4 in a population-based cohort including 7,551 unrelated Korean from Ansan and Ansung. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in SLC4A4 gene with blood pressure traits. By examining genotype data of a total of 7,551 subjects in the Korean Association REsource (KARE) study, we discovered the SLC4A4 gene polymorphisms are associated with blood pressure and hypertension. The common and highest significant polymorphism was rs6846301 (β=0.839, additive P=0.032) with systolic blood pressure (SBP), rs6846301 (β=0.588, additive P=0.027) with diastolic blood pressure (DBP), and rs6846301 (OR=1.23, CI: 1.09~1.40, additive P=1.2 × 10-3) with hypertension. Furthermore, the SNP rs6846301 was consistently associated with both blood pressure and hypertension. Consequently, we found statistically significant SNPs in SLC4A4 gene that are associated with both blood pressure and hypertension traits. In addition, these results suggest that the individuals with the minor alleles of the SNP in the SLC4A4 gene may be more susceptible to the development of hypertension in the Korean population.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Adeyemo A / 2009 / A genome-wide association study of hypertension and blood pressure in African Americans / PLoS Genetics 5:1000564
Cho YS / 2009 / A large-scale genomewide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Fiermonte G / 2009 / A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3', 5'-diphosphate in human mitochondria / J Biol Chem 284:18152~18159
Fox ER / 2011 / International Consortium for Blood Pressure Genome-wide Association Studies (ICBPGWAS), Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study / Human Molecular Genetics 20:2273~2284
Gawenis LR / 2007 / Colonic anion secretary defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3 - cotransporter / J Biol Chem 282:9042~9052
Cho YS / 2009 / A large-scale genomewide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Fiermonte G / 2009 / A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3', 5'-diphosphate in human mitochondria / J Biol Chem 284:18152~18159
Fox ER / 2011 / International Consortium for Blood Pressure Genome-wide Association Studies (ICBPGWAS), Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study / Human Molecular Genetics 20:2273~2284
Gawenis LR / 2007 / Colonic anion secretary defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3 - cotransporter / J Biol Chem 282:9042~9052
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UCI(KEPA) : I410-ECN-0101-2014-510-000614337