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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 287 - 293 (7page)
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초록· 키워드
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Objectives：The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population.
Methods：Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software.
Results：All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD.
Conclusion：Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.
Methods：Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software.
Results：All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD.
Conclusion：Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.
목차
서론
대상 및 방법
결과
고찰
결론
References
참고문헌 (30)
참고문헌 신청
American Psychiatric Association / 1994 / Diagnostic and statistical manual of mental disorders / American Psychiatric Association Press
Fombonne E / 2003 / The prevalence of autism / JAMA 289:87~89
Gillberg C / 1999 / Autism: not an extremely rare disorder / Acta Psychiatr Scand 99:399~406
Bailey A / 1995 / Autism as a strongly genetic disorder: evidence from a British twin study / Psychol Med 25:63~77
Südhof TC / 2008 / Neuroligins and neurexins link synaptic function to cognitive disease / Nature 455:903~911
Fombonne E / 2003 / The prevalence of autism / JAMA 289:87~89
Gillberg C / 1999 / Autism: not an extremely rare disorder / Acta Psychiatr Scand 99:399~406
Bailey A / 1995 / Autism as a strongly genetic disorder: evidence from a British twin study / Psychol Med 25:63~77
Südhof TC / 2008 / Neuroligins and neurexins link synaptic function to cognitive disease / Nature 455:903~911
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UCI(KEPA) : I410-ECN-0101-2014-516-000733577