지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 243 - 249 (7page)
이용수
초록· 키워드
오류제보하기
Propolis, a natural product derived from plant resins collected by honeybees, has been reported to exert a wide spectrum of biological functions. Although it has been reported that propolis and its active constituents inhibited the proliferation and growth of tumor cells by inducing apoptosis, the effect of propolis on cell death and growth is still controversial. This research aimed at investigating the effect of propolis on UV-induced apoptosis of human keratinocyte HaCaT cells. Phase contrast microscope showed that pretreatment of HaCaT cells with propolis (1~3μg/ml) protected UV-induced cell damage. Using Hoechst staining, it was demonstrated that propolis significantly inhibited the apoptosis of HaCaT cells induced by UV-irradiation. To investigate the role of ROS in UV-induced apoptosis and protection by propolis, the generation of ROS was determined in cells by using ROSdetecting fluorescent dye DCF-DA. The results showed that although the generation of ROS was markedly increased in UV-irradiated HaCaT cells, it was significantly reduced in cells pretreated with propolis (1~3μg/ml). Consequently, propolis protected human keratinocyte HaCaT cells against UVinduced apoptosis, which might be related to the reduction of ROS generation by UV-irradiation.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
ACKNOWLEDGEMENTS
LITERATURE CITED
참고문헌 (47)
참고문헌 신청
Ahn, M.R. / 2007 / Suppression of tumorinduced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation / Cancer Lett 252:235~243
Arora, R / 2005 / Radioprotective and antioxidant properties of lowaltitude Podophyllum hexandrum (LAPH) / J. Environ. Pathol. Toxicol. Oncol 24:299~314
Aso, K. / 2004 / Inhibitory effect of propolis on the growth of human leukemia U937 / Biol. Pharm. Bull 27:727~730
Bankova, V. / 2005 / Chemical diversity of propolis and the problem of standardization / J . Ethnopharmacol 100:114~117
Banskota, A.H. / 2001 / Recent progress in pharmacological research of propolis / Phytotherapy Research 15:561~571
Arora, R / 2005 / Radioprotective and antioxidant properties of lowaltitude Podophyllum hexandrum (LAPH) / J. Environ. Pathol. Toxicol. Oncol 24:299~314
Aso, K. / 2004 / Inhibitory effect of propolis on the growth of human leukemia U937 / Biol. Pharm. Bull 27:727~730
Bankova, V. / 2005 / Chemical diversity of propolis and the problem of standardization / J . Ethnopharmacol 100:114~117
Banskota, A.H. / 2001 / Recent progress in pharmacological research of propolis / Phytotherapy Research 15:561~571
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UCI(KEPA) : I410-ECN-0101-2014-527-000731047