지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 96 - 103 (8page)
이용수
초록· 키워드
오류제보하기
Objectives: 5-Hydroxymethylfurfural (HMF) regularly occurs in foods and in alcoholic beverages. However, the risk of HMF associated with alcohol consumption has not been systematically studied, so that this study will provide the first quantitative risk assessment of HMF for consumers of alcoholic beverages.
Methods: Human dietary intake of HMF via alcoholic beverages in the European Union was estimated based on WHO alcohol consumption data combined with our own survey data (n=944) and literature data (n=147) about the HMF contents of different beverage groups (beer, wine, spirits and unrecorded alcohol). The risk assessment was conducted using the margin of exposure (MOE) approach.
Results: For olfactory epithelium metaplasia in female mice, a benchmark dose (BMD) of 127 mg/kg bodyweight (bw)/d and a BMD lower confidence limit (BMDL) of 79 mg/kg bw/d were calculated from National Toxicology Program oral long-term animal experiments. The average human exposure to HMF from alcoholic beverages was estimated at 6.0E-3 mg/kg bw/d, which is approximately 8.5% of the total dietary exposure. In comparison of the human exposure with BMDL, the MOE was 13,167 for average alcohol consumption scenarios, which is a value that would be generally assumed as safe for threshold based compounds.
Conclusions: The results show that the risk from HMF to the alcohol-consuming population is rather low and the priority for risk management (e.g. to reduce the contamination) is also low. Further toxicological research about HMF is required to further elucidate its mechanism.
Methods: Human dietary intake of HMF via alcoholic beverages in the European Union was estimated based on WHO alcohol consumption data combined with our own survey data (n=944) and literature data (n=147) about the HMF contents of different beverage groups (beer, wine, spirits and unrecorded alcohol). The risk assessment was conducted using the margin of exposure (MOE) approach.
Results: For olfactory epithelium metaplasia in female mice, a benchmark dose (BMD) of 127 mg/kg bodyweight (bw)/d and a BMD lower confidence limit (BMDL) of 79 mg/kg bw/d were calculated from National Toxicology Program oral long-term animal experiments. The average human exposure to HMF from alcoholic beverages was estimated at 6.0E-3 mg/kg bw/d, which is approximately 8.5% of the total dietary exposure. In comparison of the human exposure with BMDL, the MOE was 13,167 for average alcohol consumption scenarios, which is a value that would be generally assumed as safe for threshold based compounds.
Conclusions: The results show that the risk from HMF to the alcohol-consuming population is rather low and the priority for risk management (e.g. to reduce the contamination) is also low. Further toxicological research about HMF is required to further elucidate its mechanism.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONFLICT OF INTEREST
REFERENCES
참고문헌 (40)
참고문헌 신청
Bachmann S / 1997 / 5- Hydroxymethyl-2-furfural(HMF) in Lebensmitteln / Lebensmittelchemie 51(3):49~50
Husøy T / 2008 / Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of shortterm exposure / Food Chem Toxicol 46(12):3697~3702
Iglesia Fdela / 1997 / Automatic determination of 5-hydroxymethylfurfural (5-HMF) by a flow injection method / Food Chem 60(2):245~250
Ulbricht RJ / 1984 / A review of 5- hydroxymethylfurfural (HMF) in parenteral solutions / Fundam Appl Toxicol 4(5):843~853
National Toxicology Program / NTP toxicology and carcinogenesis studies of 5-(hydroxymethyl)-2-furfural (CAS No. 67-47-0) in F344/N rats and B6C3F1 mice (gavage studies)
Husøy T / 2008 / Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of shortterm exposure / Food Chem Toxicol 46(12):3697~3702
Iglesia Fdela / 1997 / Automatic determination of 5-hydroxymethylfurfural (5-HMF) by a flow injection method / Food Chem 60(2):245~250
Ulbricht RJ / 1984 / A review of 5- hydroxymethylfurfural (HMF) in parenteral solutions / Fundam Appl Toxicol 4(5):843~853
National Toxicology Program / NTP toxicology and carcinogenesis studies of 5-(hydroxymethyl)-2-furfural (CAS No. 67-47-0) in F344/N rats and B6C3F1 mice (gavage studies)
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-539-000804729