지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 88 - 95 (8page)
이용수
초록· 키워드
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Objectives: Recent studies have shown that nano-sized carbon black is more toxic than large respirable carbon black because of its higher surface area. However, it is not clear if carbon black made larger by agglomeration demonstrates decreased toxicity. The purpose of this study was to verify if agglomeration affects the toxicity of carbon black using three differently prepared nano-sized carbon black aerosols in nose-only inhalation chambers for 13 weeks.
Methods: Printex 90 was selected as a representative nano-sized carbon black. To generate aerosols of three different types of agglomerates, Printex 90 was dispersed in distilled water by three different methods: vortex, vortex+sonication, and vortex+sonication with dispersion in a stabilizer. Then, the three differently prepared solutions were aerosolized through venturi nozzles. Male Sprague-Dawley rats were exposed to Printex 90 aerosols in a nose-only exposure chamber for 6 h/d, 5 d/wk for 13 weeks at a concentration of approximately 9 mg/㎥.
Results: Numbers of total cells in the bronchoalveolar lavage (BAL) fluid, macrophages, and polymorphonuclear leukocytes were increased and carbon black masses were clearly seen in BAL cells and lung tissues of rats exposed to Printex 90. However, few differences were found between the three differently agglomerated aerosols. In addition, there were no significant differences in other parameters, such as body weight, lung function or cytokine levels in BAL fluid following carbon black exposure.
Conclusions: Only mild to moderate respiratory effects were found in rats exposed to nano-sized carbon black at 9 mg/㎥ for 13 weeks. Agglomeration did not affect the toxicity of nano-sized carbon particles.
Methods: Printex 90 was selected as a representative nano-sized carbon black. To generate aerosols of three different types of agglomerates, Printex 90 was dispersed in distilled water by three different methods: vortex, vortex+sonication, and vortex+sonication with dispersion in a stabilizer. Then, the three differently prepared solutions were aerosolized through venturi nozzles. Male Sprague-Dawley rats were exposed to Printex 90 aerosols in a nose-only exposure chamber for 6 h/d, 5 d/wk for 13 weeks at a concentration of approximately 9 mg/㎥.
Results: Numbers of total cells in the bronchoalveolar lavage (BAL) fluid, macrophages, and polymorphonuclear leukocytes were increased and carbon black masses were clearly seen in BAL cells and lung tissues of rats exposed to Printex 90. However, few differences were found between the three differently agglomerated aerosols. In addition, there were no significant differences in other parameters, such as body weight, lung function or cytokine levels in BAL fluid following carbon black exposure.
Conclusions: Only mild to moderate respiratory effects were found in rats exposed to nano-sized carbon black at 9 mg/㎥ for 13 weeks. Agglomeration did not affect the toxicity of nano-sized carbon particles.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST
REFERENCES
참고문헌 (34)
참고문헌 신청
Ferin J / 1990 / Increased pulmonary toxicity of ultrafine particles? I. Particle clearance, translocation, morphology / J Aerosol Sci 21(3):381~384
Oberdoster G / 1991 / Increased toxicity of ultrafine particles? II. Lung lavage studies / J Aerosol Sci 21(3):384~387
Sager TM / 2007 / Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity / Nanotoxicology 1(2):118~129
Bihari P / 2008 / Optimized dispersion of nanoparticles for biological in vitro and in vivo studies / Part Fibre Toxicol 5:14
Driscoll KE / 1996 / Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black / Toxicol Appl Pharmacol 136(2):372~380
Oberdoster G / 1991 / Increased toxicity of ultrafine particles? II. Lung lavage studies / J Aerosol Sci 21(3):384~387
Sager TM / 2007 / Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity / Nanotoxicology 1(2):118~129
Bihari P / 2008 / Optimized dispersion of nanoparticles for biological in vitro and in vivo studies / Part Fibre Toxicol 5:14
Driscoll KE / 1996 / Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black / Toxicol Appl Pharmacol 136(2):372~380
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UCI(KEPA) : I410-ECN-0101-2014-539-000804714