지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 32 - 38 (7page)
이용수
초록· 키워드
오류제보하기
Objectives: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted to investigate practical use and toxic effects on neuro-immune interaction of modafinil.
Methods: This study reviewed the significance of psychoactive drugs, and discussed the benefits and risks of the application of modafinil, which seems to be ideal as an anti-psychotic or anti-fatigue agent.
Results: Modafinil is known to have less or no adverse effects than those found in traditional psychostimulants such as amphetamine, methylphenidate or cocaine. It can be applied as an anti-psychotic or anti-fatigue agent. However, the waking mechanism of modafinil is yet to be fully revealed. Recent studies reported that modafinil may be subject to abuse and addiction. In addition prolonged sleeplessness induces stress responses and impairs immune function.
Conclusions: Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.
Methods: This study reviewed the significance of psychoactive drugs, and discussed the benefits and risks of the application of modafinil, which seems to be ideal as an anti-psychotic or anti-fatigue agent.
Results: Modafinil is known to have less or no adverse effects than those found in traditional psychostimulants such as amphetamine, methylphenidate or cocaine. It can be applied as an anti-psychotic or anti-fatigue agent. However, the waking mechanism of modafinil is yet to be fully revealed. Recent studies reported that modafinil may be subject to abuse and addiction. In addition prolonged sleeplessness induces stress responses and impairs immune function.
Conclusions: Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.
목차
INTRODUCTION
PSYCHOSTIMULANTS
PHARMACOLOGICAL ECHANISM OF MODAFINIL
APPLICATION FOR THE COUNTERMEASURE OF FATIGUE
CONCLUSIONS
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST
REFERENCES
참고문헌 (64)
참고문헌 신청
Happe S / 2003 / Excessive daytime sleepiness and sleep disturbances in patients with neurological diseases: epidemiology and management / Drugs 63(24):2725~2737
Kim D / 2011 / Studies on neuroimmune regulation of psychoactive drug, modafinil / Proceedings of the Korea Institute of Military Science and Technology :1518~1521
Mignot E. / 2004 / An update on the pharmacotherapy of excessive daytime sleepiness and cataplexy / Sleep Med Rev 8(5):333~338
Robertson P Jr / 2003 / Clinical pharmacokinetic profile of modafinil / Clin Pharmacokinet 42(2):123~137
Harsh JR / 2006 / The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy / Curr Med Res Opin 22(4):761~774
Kim D / 2011 / Studies on neuroimmune regulation of psychoactive drug, modafinil / Proceedings of the Korea Institute of Military Science and Technology :1518~1521
Mignot E. / 2004 / An update on the pharmacotherapy of excessive daytime sleepiness and cataplexy / Sleep Med Rev 8(5):333~338
Robertson P Jr / 2003 / Clinical pharmacokinetic profile of modafinil / Clin Pharmacokinet 42(2):123~137
Harsh JR / 2006 / The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy / Curr Med Res Opin 22(4):761~774
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UCI(KEPA) : I410-ECN-0101-2014-539-000804643