지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.83 No.5
- 발행연도
- 2012.11
- 수록면
- 288 - 297 (10page)
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초록· 키워드
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Purpose: We evaluated the short- and long-term outcomes of laparoscopic total proctocolectomy with ileal pouch-anal anastomosis (TPC/IPAA) for treatment of familial adenomatous polyposis (FAP). Also, we assessed the oncologic outcomes in FAP patients with coexisting malignancy. Methods: From August 1999 to September 2010, 43 FAP patients with or without coexisting malignancy underwent TPC/IPAA by a laparoscopic-assisted or hand-assisted laparoscopic surgery. Results: The median age was 33 years (range, 18 to 58 years) at the time of operation. IPAA was performed by a hand-sewn method in 21 patients (48.8%). The median operative time was 300 minutes (range, 135 to 610 minutes), which reached a plateau after 22 operations. Early postoperative complications within 30 days occurred in 7 patients (16.3%) and long-term morbidity occurred in 15 patients (34.9%) including 6 (14.0%) with desmoid tumors and 3 (7.0%) who required operative treatment. Twenty-two patients (51.2%) were diagnosed with coexisting colorectal malignancy. The median follow-up was 58.5 months (range, 7.9 to 97.8 months). There was only 1 case of local recurrence in the pelvic cavity. No cases of adenocarcinoma at the residual rectal mucosa developed. 5-year disease-free survival rate for 22 patients who had coexisting malignancy was 86.5% and 5-year overall survival rate was 92.6%. Three patients died from pulmonary or hepatic metastasis. Conclusion: Laparoscopic TPC/IPAA in patients with FAP is feasible and offers favorable postoperative outcomes. It also delivered acceptable oncological outcomes in patients with coexisting malignancy. Therefore, laparoscopic TPC/IPAA may be a favorable treatment option for FAP.
목차
Abstract
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Sampson JR / 2003 / Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH / Lancet 362 : 39 ~ 41
2. [학술지(정기간행물)] - Church JM / 2002 / Teenagers with familial adenomatous polyposis: what is their risk for colorectal cancer? / Dis Colon Rectum 45 : 887 ~ 889
3. [학술지(정기간행물)] - van Duijvendijk P / 1999 / Functional outcome after colectomy and ileorectal anastomosis compared with proctocolectomy and ileal pouch- anal anastomosis in familial adenomatous polyposis / Ann Surg 230 : 648 ~ 654
4. [학술지(정기간행물)] - Andersson T / 2011 / Long-term functional outcome and quality of life after restorative proctocolectomy with ileo-anal anastomosis for colitis / Colorectal Dis 13 : 431 ~ 437
5. [학술지(정기간행물)] - Wexner SD / 1992 / Laparoscopic total abdominal colectomy. A prospective trial / Dis Colon Rectum 35 : 651 ~ 655
2. [학술지(정기간행물)] - Church JM / 2002 / Teenagers with familial adenomatous polyposis: what is their risk for colorectal cancer? / Dis Colon Rectum 45 : 887 ~ 889
3. [학술지(정기간행물)] - van Duijvendijk P / 1999 / Functional outcome after colectomy and ileorectal anastomosis compared with proctocolectomy and ileal pouch- anal anastomosis in familial adenomatous polyposis / Ann Surg 230 : 648 ~ 654
4. [학술지(정기간행물)] - Andersson T / 2011 / Long-term functional outcome and quality of life after restorative proctocolectomy with ileo-anal anastomosis for colitis / Colorectal Dis 13 : 431 ~ 437
5. [학술지(정기간행물)] - Wexner SD / 1992 / Laparoscopic total abdominal colectomy. A prospective trial / Dis Colon Rectum 35 : 651 ~ 655
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UCI(KEPA) : I410-ECN-0101-2014-514-000804362