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논문 기본 정보

자료유형
학술저널
저자정보
Sang-IL Min (Seoul National University College of Medicine) Young Suk Park (Seoul National University College of Medicine) Sanghyun Ahn (Seoul National University College of Medicine) Taejin Park (Seoul National University College of Medicine) Dae Do Park (Seoul National University College of Medicine) Suh Min Kim (Seoul National University College of Medicine) Kyung Chul Moon (Seoul National University College of Medicine) Seung-Kee Min (Seoul National University College of Medicine) Yon Su Kim (Seoul National University College of Medicine) Curie Ahn (Seoul National University College of Medicine) Sang Joon Kim (Seoul National University College of Medicine) Jongwon Ha (Seoul National University College of Medicine)
저널정보
대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.83 No.6
발행연도
2012.12
수록면
343 - 351 (9page)

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초록· 키워드

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Purpose: This study investigated the impact of subclinical borderline changes on the development of chronic allograft injury in patients using a modern immunosuppression protocol. Methods: Seventy patients with stable renal allograft function and who underwent protocol biopsies at implantation, 10 days and 1 year after transplantation were included and classified based on biopsy findings at day 10. The no rejection (NR) group included 33 patients with no acute rejection. The treatment (Tx) group included 21 patients with borderline changes following steroid pulse therapy, and the nontreatment (NTx) group included 16 patients with borderline changes nontreated. Results: The Banff Chronicity Score (BChS) and modified BChS (MBChS) were not different among the three groups at implantation (P = 0.48) or on day 10 (P = 0.96). Surprisingly, the NTx group had more prominent chronic scores at the 1-year biopsy, including BChS (3.07 ± 1.33, P = 0.005) and MBChS (3.14 ± 1.41, P = 0.008) than those in the Tx and NR group, and deterioration of BChS was more noticeable in the NTx group (P = 0.037), although renal function was stable (P = 0.66). No difference in chronic injury scores was observed between the Tx and NR groups at the 1-year biopsy. Conclusion: Subclinical borderline changes can be a risk factor for chronic allograft injury and should be considered for antirejection therapy.

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Abstract
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
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UCI(KEPA) : I410-ECN-0101-2014-514-000804226