Clinicopathological features of the intraductal papillary neoplasms of the intrahepatic bile duct

Gi-Woong Jang; Shin Hwang; Yong-Joo Lee; Ki-Hun Kim; Kwang-Min Park; Chul-Soo Ahn; Deok-Bog Moon; Tae-Yong Ha; Gi-Won Song; Dong-Hwan Jung; Gil-Chun Park; Sung-Gyu Lee

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자료유형: 학술저널

저자정보: Gi-Woong Jang (University of Ulsan College of Medicine) Shin Hwang (University of Ulsan College of Medicine) Yong-Joo Lee (University of Ulsan College of Medicine) Ki-Hun Kim (University of Ulsan College of Medicine) Kwang-Min Park (University of Ulsan College of Medicine) Chul-Soo Ahn (University of Ulsan College of Medicine) Deok-Bog Moon (University of Ulsan College of Medicine) Tae-Yong Ha (University of Ulsan College of Medicine) Gi-Won Song (University of Ulsan College of Medicine) Dong-Hwan Jung (University of Ulsan College of Medicine) Gil-Chun Park (University of Ulsan College of Medicine) Sung-Gyu Lee (University of Ulsan College of Medicine)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제16권 제4호

발행연도: 2012.12

수록면: 138 - 141 (4page)

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Backgrounds/Aims: This study is intended to investigate the clinicopathological features of the intraductal papillary neoplasms of the intrahepatic bile duct (IPNB), especially focused on malignant changes. Methods: From the institutional database of liver resection cases (Asan Medical Center, University of Ulsan College of Medicine), 18 patients who met the definition of IPNB were selected. They had undergone liver resection between February 2002 and October 2006; thus, the follow-up period was more than 5 years. Results: Of the 18 patients, 11 patients were male. Their mean age was 61.3±6.7 years. There were no differences between the non-malignant and malignant lesions, in the comparison of the CEA levels (5.6±2.7 vs.12.6±31.1 ng/ml, p=0.439) and the CA19-9 levels (29.2±34.7 vs.31.9±30.2 ng/ml, p=0.871). The common radiologic findings were: intraductal growing mass in 10; bile duct dilatation in 6; and saccular duct dilatation in 2. Left and right hepatectomies were performed in 15 and 3, respectively. Five patients showed benign lesions of IPNB, and 13 patients revealed malignant lesions of intraductal papillary adnocarcinoma or cholangiocarcinoma. All 4 patients with benign lesions survived for a mean period of 53 months without recurrence. In 13 patients with the malignant lesions, 1-year, 3-year, and 5-year survival rates were 100%, 84.6%, and 59.2%, respectively. Conclusions: We concluded that intrahepatic IPNB is a rare type of biliary neoplasm which includes a histological spectrum, ranging from benign disease to invasive malignancy. The long-term survival was anticipated after complete curative resection. (Korean J Hepatobiliary Pancreat Surg 2012;16:138-141)

#Intraductal papillary neoplasm #Intrahepatic duct #Resection

참고문헌 (14)

참고문헌 신청

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