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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 199 - 206 (8page)
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Purpose: Clinical features of Pancreatic Neuroendocrine Tumors (PETs) vary according to the hormone secreted and to the heredity of the tumors. Malignant PETs are common among nonfunctioning PETs (NFTs) whereas the majority of functioning PETs (FTs) are benign. Our goal was to determine the clinical features and prognosis of PETs stratified by the WHO classification scheme and AJCC-UICC 7TH TNM staging.
Methods: We selected for study 30 patients with PETs, including one case of nesidiolastosis, who presented at our clinic between April 1992 and June 2010. Clinicopathological features were studied retrospectively. PETs were classified as benign, uncertain malignant, well differentiated carcinoma, or poorly differentiated carcinomas by the WHO classification. For statistical analysis, Student"s t-test, the Chi-square test, and the Kaplan-Meier method were utilized.
Results: Nine cases were FTs and twenty one cases were NFTs. The average size of the FTs was smaller than that of the NFTs (1.71 vs 4.33, p=0.04). The head of the pancreas was most commonly involved (33.3% of FTs; 47.6% of NFTs) but the locations of the tumors were not different. Insulinoma was the most common (66.7%, 6/9) among FTs. The incidence of malignant tumors was 33.3% and 55.0% among, respectively, FTs and NFTs. The 5-year disease-free survival rate of patients with benign PETs (FTs and NFTs), and of patients with functioning well-differentiated carcinomas was 100%. However, the 5-year disease-free survival rates of patients with nonfunctioning well- and poorly-differentiated carcinomas were 66.7% and 0%.
Conclusion: Among patients with Pancreatic Neuroendocrine Tumors, malignant tumors are more common among NFTs than FTs. Poorly-differentiated carcinomas have a worse prognosis while all FTs regardless of their WHO classification fail to show any disease recurrence.
Methods: We selected for study 30 patients with PETs, including one case of nesidiolastosis, who presented at our clinic between April 1992 and June 2010. Clinicopathological features were studied retrospectively. PETs were classified as benign, uncertain malignant, well differentiated carcinoma, or poorly differentiated carcinomas by the WHO classification. For statistical analysis, Student"s t-test, the Chi-square test, and the Kaplan-Meier method were utilized.
Results: Nine cases were FTs and twenty one cases were NFTs. The average size of the FTs was smaller than that of the NFTs (1.71 vs 4.33, p=0.04). The head of the pancreas was most commonly involved (33.3% of FTs; 47.6% of NFTs) but the locations of the tumors were not different. Insulinoma was the most common (66.7%, 6/9) among FTs. The incidence of malignant tumors was 33.3% and 55.0% among, respectively, FTs and NFTs. The 5-year disease-free survival rate of patients with benign PETs (FTs and NFTs), and of patients with functioning well-differentiated carcinomas was 100%. However, the 5-year disease-free survival rates of patients with nonfunctioning well- and poorly-differentiated carcinomas were 66.7% and 0%.
Conclusion: Among patients with Pancreatic Neuroendocrine Tumors, malignant tumors are more common among NFTs than FTs. Poorly-differentiated carcinomas have a worse prognosis while all FTs regardless of their WHO classification fail to show any disease recurrence.
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참고문헌
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Eriksson B / 2000 / Neuroendocrine tumours of the pancreas / Br J Surg 87 : 129 ~ 131
2. [학술지(정기간행물)] - Oberg K / 2005 / Endocrine tumours of the pancreas / Best Pract Res Clin Gastroenterol 19 : 753 ~ 781
3. [학술지(정기간행물)] - Vasen HF / 1989 / Screening for the multiple endocrine neoplasia syndrome type I. A study of 11 kindreds in The Netherlands / Arch Intern Med 149 : 2717 ~ 2722
4. [학술지(정기간행물)] - Skogseid B / 1991 / Multiple endocrine neoplasia type 1: a 10-year prospective screening study in four kindreds / J Clin Endocrinol Metab 73 : 281 ~ 287
5. [학술지(정기간행물)] - Binkovitz LA / 1990 / Islet cell tumors in von Hippel-Lindau disease: increased prevalence and relationship to the multiple endocrine neoplasias / AJR Am J Roentgenol 155 : 501 ~ 505
2. [학술지(정기간행물)] - Oberg K / 2005 / Endocrine tumours of the pancreas / Best Pract Res Clin Gastroenterol 19 : 753 ~ 781
3. [학술지(정기간행물)] - Vasen HF / 1989 / Screening for the multiple endocrine neoplasia syndrome type I. A study of 11 kindreds in The Netherlands / Arch Intern Med 149 : 2717 ~ 2722
4. [학술지(정기간행물)] - Skogseid B / 1991 / Multiple endocrine neoplasia type 1: a 10-year prospective screening study in four kindreds / J Clin Endocrinol Metab 73 : 281 ~ 287
5. [학술지(정기간행물)] - Binkovitz LA / 1990 / Islet cell tumors in von Hippel-Lindau disease: increased prevalence and relationship to the multiple endocrine neoplasias / AJR Am J Roentgenol 155 : 501 ~ 505
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