지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.9
- 수록면
- 164 - 169 (6page)
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초록· 키워드
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Alpha-synuclein (α-syn) is a presynaptic protein that is richly expressed in the central and peripheral nervous systems of mammals, and it is related to the pathogenesis of Parkinson’s disease and other neurodegenerative disorders. In the present study, we compared the distribution of the immunoreactivity of α-syn and its related gliosis in the spinal cord of young adult (2-3 years) and aged (10-12 years) beagle dogs. We discovered that α-syn immunoreactivity was present in many neurons in the thoracic level of the aged spinal cord, however, its protein level was not distinct inform that of the adult spinal cord. In addition, ionized calcium-binding adapter molecule-1 (a marker for microglia) immunoreactivity, and not glial fibrillary acidic protein (a marker for astrocytes) immunoreactivity, was somewhat increased in the aged group compared to the adult group. These results indicate that α-syn immunoreactivity was not dramatically changed in the dog spinal cord during aging.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (28)
참고문헌 신청
Abeliovich A / 2000 / Mice lacking alphasynuclein display functional deficits in the nigrostriatal dopamine system / Neuron 25(1):239~252
Totterdell S / 2005 / Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain / Neuroscience 135(3):907~913
Li JY / 2002 / Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS / Neuroscience 113(2):463~478
Irizarry MC / 1996 / Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system / J Neuropathol Exp Neurol 55(8):889~895
Kahle PJ / 2000 / Subcellular localization of wild-type and Parkinson’s disease-associated mutant alpha - synuclein in human and transgenic mouse brain / J Neurosci 20(17):6365~6373
Totterdell S / 2005 / Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain / Neuroscience 135(3):907~913
Li JY / 2002 / Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS / Neuroscience 113(2):463~478
Irizarry MC / 1996 / Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system / J Neuropathol Exp Neurol 55(8):889~895
Kahle PJ / 2000 / Subcellular localization of wild-type and Parkinson’s disease-associated mutant alpha - synuclein in human and transgenic mouse brain / J Neurosci 20(17):6365~6373
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UCI(KEPA) : I410-ECN-0101-2014-510-001260371