지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 83 - 89 (7page)
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초록· 키워드
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Purpose: Although surgical resection offers patients with HCC the chance of a cure, the post-resection tumor recurrence rate is high, with reported cumulative 5-year tumor recurrence rates ranging from 40 to 70%. The objective of this study was to investigate risk factors for intrahepatic recurrence after resection of hepatocellular carcinoma, especially in patients with hepatitis B virus infection.
Methods: Between January 1999 and December 2003, 59 patients in our Hospital with hepatitis B virus infection underwent liver resection for hepatocellular carcinoma. Clinical, biological, and histopathological characteristics of these patients were collected and tested for their prognostic significance using a Chi-square test and a Student"s t-test. Time to recurrence and survival rate were analyzed by the Kaplan-Meier method.
Results: Of the 59 patients who underwent liver resection, 24 (41%) experienced intrahepatic recurrence. The 1-, 3-, and 5-year overall survival rates of total enrolled patients were 83%, 63%, and 42%, respectively. The 1-, 3-, and 5-year overall survival rates after recurrence were 87%, 52%, and 20%, respectively. The risk factors for early recurrence were elevated serum aspartate aminotransferase (AST) level (p=0.044) and larger tumor size (p=0.049). For late recurrence, greater tumor size (p=0.039) was the only risk factor.
Conclusion: Tumor size and serum aspartate aminotransferase are risk factors of intrahepatic recurrence after resection of HCC in patients with chronic hepatitis B virus infection. This finding indicates that patients who have these risk factors should be under more careful supervision and have more aggressive follow-up.
Methods: Between January 1999 and December 2003, 59 patients in our Hospital with hepatitis B virus infection underwent liver resection for hepatocellular carcinoma. Clinical, biological, and histopathological characteristics of these patients were collected and tested for their prognostic significance using a Chi-square test and a Student"s t-test. Time to recurrence and survival rate were analyzed by the Kaplan-Meier method.
Results: Of the 59 patients who underwent liver resection, 24 (41%) experienced intrahepatic recurrence. The 1-, 3-, and 5-year overall survival rates of total enrolled patients were 83%, 63%, and 42%, respectively. The 1-, 3-, and 5-year overall survival rates after recurrence were 87%, 52%, and 20%, respectively. The risk factors for early recurrence were elevated serum aspartate aminotransferase (AST) level (p=0.044) and larger tumor size (p=0.049). For late recurrence, greater tumor size (p=0.039) was the only risk factor.
Conclusion: Tumor size and serum aspartate aminotransferase are risk factors of intrahepatic recurrence after resection of HCC in patients with chronic hepatitis B virus infection. This finding indicates that patients who have these risk factors should be under more careful supervision and have more aggressive follow-up.
목차
Introduction
Methods
Results
Discussion
Conclusion
References
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Tan A / 2008 / Viral hepatocarcinogenesis: from infection to cancer / Liver Int 28 : 175 ~ 188
2. [보고서] - Ministry of Health and Welfare / 2003 / 2002 Annual Report of the Korea Central Cancer Registry
3. [학술지(정기간행물)] - Shah SA / 2006 / Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes / J Am Coll Surg 202 : 275 ~ 283
4. [학술지(정기간행물)] - Chen WT / 2004 / Recurrent hepatocellular carcinoma after hepatic resection: prognostic factors and long-term outcome / Eur J Surg Oncol 30 : 414 ~ 420
5. [학술지(정기간행물)] - Park KW / 2008 / Survival analysis of 904 patients with hepatocellular carcinoma in a hepatitis B virus-endemic area / J Gastroenterol Hepatol 23 : 467 ~ 473
2. [보고서] - Ministry of Health and Welfare / 2003 / 2002 Annual Report of the Korea Central Cancer Registry
3. [학술지(정기간행물)] - Shah SA / 2006 / Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes / J Am Coll Surg 202 : 275 ~ 283
4. [학술지(정기간행물)] - Chen WT / 2004 / Recurrent hepatocellular carcinoma after hepatic resection: prognostic factors and long-term outcome / Eur J Surg Oncol 30 : 414 ~ 420
5. [학술지(정기간행물)] - Park KW / 2008 / Survival analysis of 904 patients with hepatocellular carcinoma in a hepatitis B virus-endemic area / J Gastroenterol Hepatol 23 : 467 ~ 473
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UCI(KEPA) : I410-ECN-0101-2014-514-001274468