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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 67 - 77 (11page)
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There are many limitations for conducting liver disease research in human beings due to the high cost and potential ethical issues. For this reason, conducting a study that is difficult to perform in humans using appropriate animal models, can be beneficial in ascertaining the pathological physiology, and in developing new treatment modalities. However, it is difficult to determine the appropriate animal model which is suitable for research purposes, since every patient has different and diverse clinical symptoms, adverse reactions, and complications due to the pathological physiology. Also, it is not easy to reproduce identically various clinical situations in animal models. Recently, the Guide for the Care and Use of Laboratory Animals has tightened up the regulations, and therefore it is advisable to select the appropriate animals and decide upon the appropriate quantities through scientific and systemic considerations before conducting animal testing. Therefore, in this review article the authors examined various white rat animal testing models and determined the appropriate usable rat model, and the pros and cons of its application in liver disease research. The authors believe that this review will be beneficial in selecting proper laboratory animals for research purposes.
목차
Introduction
Acquisition of the Experimental Animal Model
Rat Strains
Liver Disease Experimental Animal Models
Conclusions
References
참고문헌 (77)
참고문헌 신청
1. [학술지(정기간행물)] - Blumberg BS / 1985 / The Daedalus effect: changes in ethical questions relating to hepatitis B virus / Ann Intern Med 102 : 390 ~ 394
2. [학술지(정기간행물)] - Mullen KD / 1989 / Problems with animal models of chronic liver disease: suggestions for improvement in standardization / Hepatology 9 : 500 ~ 503
3. [학술지(정기간행물)] - Fourneau I / 2000 / An improved model of acute liver failure based on transient ischemia of the liver / Arch Surg 135 : 1183 ~ 1189
4. [학술지(정기간행물)] - Newsome PN / 2000 / Animal models of fulminant hepatic failure: a critical evaluation / Liver Transpl 6 : 21 ~ 31
5. [학술지(정기간행물)] - Terblanche J / 1991 / Animal models of fulminant hepatic failure / Dig Dis Sci 36 : 770 ~ 774
2. [학술지(정기간행물)] - Mullen KD / 1989 / Problems with animal models of chronic liver disease: suggestions for improvement in standardization / Hepatology 9 : 500 ~ 503
3. [학술지(정기간행물)] - Fourneau I / 2000 / An improved model of acute liver failure based on transient ischemia of the liver / Arch Surg 135 : 1183 ~ 1189
4. [학술지(정기간행물)] - Newsome PN / 2000 / Animal models of fulminant hepatic failure: a critical evaluation / Liver Transpl 6 : 21 ~ 31
5. [학술지(정기간행물)] - Terblanche J / 1991 / Animal models of fulminant hepatic failure / Dig Dis Sci 36 : 770 ~ 774
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UCI(KEPA) : I410-ECN-0101-2014-514-001274448