지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 206 - 217 (12page)
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Backgrounds/Aims: Hepatic resection has only guaranteed long-term survival in patients with colorectal liver metastasis (CRLM) even in the era of effective chemotherapy. The definite role of neoadjuvant chemotherapy (NCT) is to improve outcomes of unresectable CRLMs, but it its role has not been defined for initially resectable CRLMs (IR-CRLMs). Methods: We reviewed the medical records of 226 patients, who had been diagnosed and treated for IR-CRLM between 2003 and 2008; the patients had the following pathologies: 10% had more than 4 nodules, 11% had tumors larger than 5 cm, and 61% had synchronous CRMLs. Among these patients, 20 patients (Group Y) were treated with NCT, and 206 (Group N) did not receive NCT according to their physician’s preference. The median follow-up time was 34.1 months. Results: The initial surgical plans were changed after NCT to further resection in 20% and to limited resection in 10% of 20 patients. Complication rates of Groups Y (30%) were indifferent from Group N (23%) (p=0.233), but intraoperative transfusions were more frequent in Group N (15%) than in Group Y (5%) (p=0.006). There was one case of hospital mortality (0.44%). Disease-free survival rates in Groups Y and N were 23% and 39%, respectively, and patient survival rates were 42% and 66% (p＞0.05). By multivariate analysis, old age (≥60 years), differentiation of primary tumor (poorly/mucinous), resection margin involvement, and no adjuvant chemotherapy were associated with poor patient survival; the number of CRLMs (≥4) was associated with poor disease-free survival. Conclusions: NCT had neither a positive impact nor a negative impact on survival, even with intraoperative transfusion, as observed on operative outcomes for patients with IR-CRLM. Further study is required to elucidate the role of NCT for treatment of patient with IR-CRLMs. (Korean J Hepatobiliary Pancreat Surg 2011;15:206-217)
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Fong Y / 1999 / Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases / Ann Surg 230 : 309 ~ 318
2. [학술지(정기간행물)] - Nordlinger B / 1996 / Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie / Cancer 77 : 1254 ~ 1262
3. [학술지(정기간행물)] - Scheele J / 1995 / Resection of colorectal liver metastases / World J Surg 19 : 59 ~ 71
4. [학술지(정기간행물)] - House MG / 2010 / Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution / J Am Coll Surg 210 : 744 ~ 755
5. [학술지(정기간행물)] - Kopetz S / 2009 / Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy / J Clin Oncol 27 : 3677 ~ 3683
2. [학술지(정기간행물)] - Nordlinger B / 1996 / Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie / Cancer 77 : 1254 ~ 1262
3. [학술지(정기간행물)] - Scheele J / 1995 / Resection of colorectal liver metastases / World J Surg 19 : 59 ~ 71
4. [학술지(정기간행물)] - House MG / 2010 / Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution / J Am Coll Surg 210 : 744 ~ 755
5. [학술지(정기간행물)] - Kopetz S / 2009 / Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy / J Clin Oncol 27 : 3677 ~ 3683
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UCI(KEPA) : I410-ECN-0101-2014-514-001273885