지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.9
- 수록면
- 299 - 306 (8page)
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Recently, the prevalence of 16S rRNA methylase conferring high-level resistance to aminoglycosides has been increasing in Gram-negative bacilli globally. We determined the prevalence and genotype of these methylase-producing bacteria, and characterized the co-resistance to β-lactam antibiotics and quinolone in Gram-negative clinical isolates collected in 2010 at a hospital in Korea. Among 65 amikacin-resistant isolates screened from 864 Gram-negative bacilli (GNB), 16S rRNA methylase genes were detected from 49 isolates, including Acinetobacter baumannii (43), Klebsiella pneumoniae (2), Proteus mirabilis (2) and Serratia marcescens (1), Empedobacter brevis (1). All of the 16S rRNA methylase genotype was armA and no variant sequences of amplified PCR products for armA were noted. The 16S rRNA methylase producing bacteria showed much higher resistance to aminoglycoside for Enterobacteriaceae and glucose non-fermenting (NF)-GNB and to imipenem for glucose NF-GNB, than the non-producing isolates. All of the 16S rRNA methylase producing Enterobacteriaceae had the extended-spectrum-β-lactamase. In addition, two K. pneumoniae concurrently produced both plasmid-mediated AmpC β-lactamase and qnrB gene. All of the amikacinresistant A. baumannii (43) co-harbored armA 16S rRNA methylase and blaOXA-23 carbapenemase. In conclusion, 16S rRNA methylase producing bacteria were very prevalent among GNB in South Korea, and were commonly associated with co-resistance, including carbapenem and quinolone.
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REFERENCES
참고문헌 (29)
참고문헌 신청
Adams-Haduch JM / 2008 / Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania / Antimicrob Agents Chemother 52:3837~3843
Bogaerts P / 2007 / Emergence of armA and rmtB aminoglycoside resistance 16S rRNA methylase in Belgium / J Antimicrobial Chemotherapy 59:459~464
Cattoir V / 2007 / Multiplex PCR for detection of plasmid-mediared quinolone resistance qnr genes in ESBL-producing enterobacterial isolates / J Antimicrob Chemother 60:394~397
Clinical and Laboratory Standards Institute / 2012 / Performance standards for antimicrobial susceptibility testing: twenty two informational supplement (M100-S22) / CLSI
Davis MA / 2010 / Discovery of a gene conferring multiful-aminoglycoside resistance in Escherichia coli / Antimicrob Agents Chemother 47:2565~2571
Bogaerts P / 2007 / Emergence of armA and rmtB aminoglycoside resistance 16S rRNA methylase in Belgium / J Antimicrobial Chemotherapy 59:459~464
Cattoir V / 2007 / Multiplex PCR for detection of plasmid-mediared quinolone resistance qnr genes in ESBL-producing enterobacterial isolates / J Antimicrob Chemother 60:394~397
Clinical and Laboratory Standards Institute / 2012 / Performance standards for antimicrobial susceptibility testing: twenty two informational supplement (M100-S22) / CLSI
Davis MA / 2010 / Discovery of a gene conferring multiful-aminoglycoside resistance in Escherichia coli / Antimicrob Agents Chemother 47:2565~2571
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UCI(KEPA) : I410-ECN-0101-2014-510-001368927