지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.8
- 수록면
- 489 - 496 (8page)
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Physical exercise is recommended as a therapeutic tool for improving functional and histological deficits in spinal cord contusion injury (SCI). Cell division cycle 2 (Cdc2) and Extracellular signal-regulated kinase 1/2 (ERK1/2) have been known to regulate proliferation of non-neuronal cells in both central and peripheral nervous system. Here we investigated the effect of activated Cdc2 and ERK1/2 by treadmill exercise on axonal regeneration of corticospinal tract and proliferation of astrocytes within the cavity after spinal cord contusion injury. The rats were divided into three groups: the control group (n = 20), the spinal cord injury group (n = 20), and spinal cord injury and treadmill exercise group (n = 20). We carried out Basso-Beattie-Bresnahan (BBB) test to determine functional recovery after spinal cord injury and treadmill exercise for 4 weeks significantly improved SCI-induced behavioral deficits (F = 25.457, p < .001). We also found that Cdc2 (F = 34.548, p < .001) and p-ERK1/2 expression (F = 311.507, p < .001) levels in the injured areas were further facilitated by treadmill exercise when compared to non-exercise group. Exercise-induced Cdc2 and p-ERK1/2 levels after SCI were associated with astrocyte proliferation within the cavity of the injury site. Also the results of present study suggested that treadmill exercise increased axonal sprouting of injured corticospinal tract post SCI. Our data provide evidence that treadmill exercise may be an important intervention for mediating axonal regeneration and biochemical alteration after SCI.
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Abstract
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2. 연구 방법
3. 결과 및 해석
4. 논의
5. 결론
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참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Anderson, K. D. / 2009 / Bilateral cervical contusion spinal cord injury in rats / Experimental neurology 220 (1) : 9 ~ 22
2. [학술지(정기간행물)] - Atalay, B. / 2007 / Antibodies neutralizing nogo-A increase pan-cadherin expression and motor recovery following spinal cord injury in rats / Spinal Cord 45 (12) : 780 ~ 786
3. [학술지(정기간행물)] - Bajetto, A. / 2001 / Chemokines and their receptors in the central nervous system / Frontiers in Neuroendocrinology 22 (3) : 147 ~ 184
4. [학술지(정기간행물)] - Basso, D. M. / 1995 / A sensitive and reliable locomotor rating scale for open field testing in rats / J. Neurotrauma 12 : 1 ~ 21
5. [학술지(정기간행물)] - 오명진 / 201206 / Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via beta 1-integrin activation / FASEB JOURNAL 26 (6) : 2401 ~ 2413
2. [학술지(정기간행물)] - Atalay, B. / 2007 / Antibodies neutralizing nogo-A increase pan-cadherin expression and motor recovery following spinal cord injury in rats / Spinal Cord 45 (12) : 780 ~ 786
3. [학술지(정기간행물)] - Bajetto, A. / 2001 / Chemokines and their receptors in the central nervous system / Frontiers in Neuroendocrinology 22 (3) : 147 ~ 184
4. [학술지(정기간행물)] - Basso, D. M. / 1995 / A sensitive and reliable locomotor rating scale for open field testing in rats / J. Neurotrauma 12 : 1 ~ 21
5. [학술지(정기간행물)] - 오명진 / 201206 / Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via beta 1-integrin activation / FASEB JOURNAL 26 (6) : 2401 ~ 2413
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UCI(KEPA) : I410-ECN-0101-2014-590-001368338