지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.17 No.3
- 발행연도
- 2012.9
- 수록면
- 177 - 183 (7page)
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초록· 키워드
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Interruption of blood flow through coronary arteries and its subsequent restoration triggers the generation of a burst of reactive oxygen species (ROS), leading to myocardial cell death. In this study, we determined whether a methanol extract of Cassia mimosoides var. nomame Makino could prevent myocardial ischemia-reperfusion injury. When radical scavenging activity of the extract was measured in vitro using its α,α-diphenyl-β-picrylhydrazyl (DPPH) radical quenching ability, the extract showed an activity slightly lower than that of ascorbic acid. Three days after oral administration of the extract (400 ㎎/㎏/day) to rats, myocardial ischemia/reperfusion injury was generated by 30 min of ligation of the left anterior descending coronary artery (LAD), followed by 3 hr reperfusion. Compared with the vehicle-treated group, administration of the extract significantly reduced infarct size (IS) (ratio of infarct area to area at risk) in the extract-treated group by 28.3%. Reduction in the cellular injury was mediated by attenuation of Bax/Bcl-2 ratio by 33.3%, inhibition of caspase-3 activation from procaspase-3 by 40%, and subsequent reduction in the number of apoptotic cells by 66.3%. These results suggest that the extract attenuates myocardial injury in a rat model of ischemia-reperfusion by scavenging ROS, including free radicals, and consequently blocking apoptotic cascades. Therefore, intake of Cassia mimosoides var. nomame Makino might be beneficial for preventing ischemic myocardial injury.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
ACKNOWLEDGMENTS
NOMENCLATURE
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Abbate A / 2006 / Acute myocardial infarction and heart failure: role of apoptosis / Int J Biochem Cell Biol 38 : 1834 ~ 1840
2. [학술지(정기간행물)] - Cohen M / 2010 / Therapy for ST-segment elevation myocardial infarction patients who present late or are ineligible for reperfusion therapy / J Am Coll Cardiol 55 : 1895 ~ 1906
3. [학술지(정기간행물)] - Nadtochiy SM / 2011 / Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids, and polyphenols / Nutrition 27 : 733 ~ 744
4. [학술지(정기간행물)] - Raedschelders K / 2012 / The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion / Pharmacol Ther 133 : 230 ~ 235
5. [학술지(정기간행물)] - Andreadou I / 2009 / To prevent, protect and save the ischemic heart: antioxidants revisited / Expert Opin Ther Targets 13 : 945 ~ 956
2. [학술지(정기간행물)] - Cohen M / 2010 / Therapy for ST-segment elevation myocardial infarction patients who present late or are ineligible for reperfusion therapy / J Am Coll Cardiol 55 : 1895 ~ 1906
3. [학술지(정기간행물)] - Nadtochiy SM / 2011 / Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids, and polyphenols / Nutrition 27 : 733 ~ 744
4. [학술지(정기간행물)] - Raedschelders K / 2012 / The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion / Pharmacol Ther 133 : 230 ~ 235
5. [학술지(정기간행물)] - Andreadou I / 2009 / To prevent, protect and save the ischemic heart: antioxidants revisited / Expert Opin Ther Targets 13 : 945 ~ 956
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