지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.83 No.4
- 발행연도
- 2012.10
- 수록면
- 227 - 236 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: Hepatobiliary surgery has changed dramatically in recent decades with the advent of laparoscopic techniques. The aim of this retrospective study was to compare survival rates according to stages, adjusting for important prognostic factors. Methods: A retrospective study of a 17-year period from January 1994 to April 2011 was carried out. The cases studied were divided into two time period cohorts, those treated in the first 9-years (n = 109) and those treated in the last 7-years (n = 109). Results: An operation with curative intent was performed on 218 patients. The 5-year survival rates according to the depth of invasion were 86% (T1), 56% (T2), 45% (T3), and 5% (T4). The number of cases of incidental gallbladder cancer found during 3,919 laparoscopic cholecystectomies was 96 (2.4%). Incidental gallbladder cancer revealed a better survival rate (P = 0.003). Iatrogenic bile spillage was found in 20 perforations of the gallbladder during laparoscopic cholecystectomies, 16 preoperative percutaneous transhepatic gallbladder drainages and 16 percutaneous transhepatic biliary drainages; only percutaneous transhepatic biliary drainage patients showed a significantly lower survival rate than patients without iatrogenic bile spillage (P ＜ 0.034). Chemoradiation appeared to improve overall survival (P ＜ 0.001). Multivariate analysis also revealed that time period, type of surgery, surgical margin, lymphovascular invasion, lymph node involvement, and chemoradiation therapy had significant effects. Conclusion: This study found that the prognosis of gallbladder cancer is still determined by the stage at presentation due to the aggressive biology of this tumor. Early diagnosis, radical resection and appropriate adjuvant therapy can increase overall survival.
목차
NTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Konstantinidis IT / 2009 / Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience / Arch Surg 144 : 441 ~ 447
2. [학술지(정기간행물)] - Goetze T / 2006 / Does laparoscopy worsen the prognosis for incidental gallbladder cancer? / Surg Endosc 20 : 286 ~ 293
3. [학술지(정기간행물)] - Shih SP / 2007 / Gallbladder cancer: the role of laparoscopy and radical resection / Ann Surg 245 : 893 ~ 901
4. [학술지(정기간행물)] - Yokomizo H / 2007 / Surgical treatment of pT2 gallbladder carcinoma: a reevaluation of the therapeutic effect of hepatectomy and extrahepatic bile duct resection based on the long- term outcome / Ann Surg Oncol 14 : 1366 ~ 1373
5. [학술지(정기간행물)] - Tanaka N / 1997 / Does bile spillage during an operation present a risk for peritoneal metastasis in bile duct carcinoma? / Surg Today 27 : 1010 ~ 1014
2. [학술지(정기간행물)] - Goetze T / 2006 / Does laparoscopy worsen the prognosis for incidental gallbladder cancer? / Surg Endosc 20 : 286 ~ 293
3. [학술지(정기간행물)] - Shih SP / 2007 / Gallbladder cancer: the role of laparoscopy and radical resection / Ann Surg 245 : 893 ~ 901
4. [학술지(정기간행물)] - Yokomizo H / 2007 / Surgical treatment of pT2 gallbladder carcinoma: a reevaluation of the therapeutic effect of hepatectomy and extrahepatic bile duct resection based on the long- term outcome / Ann Surg Oncol 14 : 1366 ~ 1373
5. [학술지(정기간행물)] - Tanaka N / 1997 / Does bile spillage during an operation present a risk for peritoneal metastasis in bile duct carcinoma? / Surg Today 27 : 1010 ~ 1014
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UCI(KEPA) : I410-ECN-0101-2014-514-001420099