지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.83 No.2
- 발행연도
- 2012.8
- 수록면
- 69 - 74 (6page)
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초록· 키워드
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Purpose: We wished to compare the clinical effectiveness of cystatin C (CyC) and serum creatinine (sCr) to assess renal function in renal transplantation patients. Methods: We compared the clinical effectiveness of CyC with that of the sCr to estimate 24-hour urine creatinine clearance (CrCl) in 72 adult recipients who underwent renal transplantation from January 2001 to December 2008. We analyzed the data in terms of accuracy, bias, precision and sensitivity as a function of length of time posttransplantation and CrCl value. Results: The patients were divided into four groups according to CrCl value ＜30, ＜60, ＜90, and ≥90 mL/min/1.73 m<SUP>2</SUP>. The corresponding Cr-based glomerular filtration rate (GFR) estimates had accuracies of 0.71, 0.906, 0.963, and 1.00 within 50% of the reference, with biases (mean percentage errors) of 4.7, 5.32, -5.79, -31.33 mL/min/1.73 m<SUP>2</SUP>, and precisions (mean absolute percentage errors) of 7.57, 10.03, 14.52, and 31.33 mL/min/1.73 m<SUP>2</SUP>, respectively. The CyC-based GFR estimates had accuracies of 0.35, 0.79, 0.93, and 0.67 within 50% of the reference, respectively, with biases of 15.03, 13.37, -5.58, and -34.79 mL/min/1.73 m<SUP>2</SUP> and precisions of 15.03, 14.80, 17.91, and 34.79 mL/min/1.73 m<SUP>2</SUP>. The sensitivity for detecting GFR below 60 mL/min/1.73 m<SUP>2</SUP> was higher for CyC (0.96, 1, and 0.95) than for Cr (0.77, 0.75, and 0.82). Conclusion: CyC is a more sensitive indicator of low GFR (CrCl ＜60 mL/min/1.73 m<SUP>2</SUP>) than sCr. However, CyC-based GFR estimates are restrictive data, and are neither accurate nor specific. Therefore, to evaluate renal function, we may need a revised CyC-based GFR formula and close monitoring of sCr.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
REFERENCES
참고문헌 (23)
참고문헌 신청
White CA / 2010 / Measuring vs estimating glomerular filtration rate in kidney transplantation / Transplant Rev 24:18~27
Newman DJ / 2002 / Ann Clin Biochem 39:89~104
Hojs R / 2006 / Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function / Nephrol Dial Transplant 21:1855~1862
Thomas C / 2009 / Renal failure--measuring the glomerular filtration rate / Dtsch Arztebl Int 106:849~854
Dharnidharka VR / 2002 / Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis / Am J Kidney Dis 40:221~226
Newman DJ / 2002 / Ann Clin Biochem 39:89~104
Hojs R / 2006 / Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function / Nephrol Dial Transplant 21:1855~1862
Thomas C / 2009 / Renal failure--measuring the glomerular filtration rate / Dtsch Arztebl Int 106:849~854
Dharnidharka VR / 2002 / Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis / Am J Kidney Dis 40:221~226
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UCI(KEPA) : I410-ECN-0101-2014-514-001417136