지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.7
- 수록면
- 7 - 13 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Leptin plays an important role in the control of body weight and also has a growth-factor-like function in epithelial cells. Abnormal expression of leptin and leptin receptor may be associated with cancer development and progression. We evaluated the relationship among leptin and leptin receptors polymorphisms, body mass index (BMI), serum leptin concentrations, and clinicopathologic features with gastric cancer and determined whether they could be the risk factor of gastric cancer. Methods: We measured the serum leptin concentrations of 48 Korean patients with gastric cancer and 48 age- and sex-matched controls. By polymerase chain reaction-restriction fragment length polymorphism, we investigated one leptin gene promoter G-2548A genotype and four leptin receptor gene polymorphisms at codons 223, 109, 343, and 656. Results: There was no significant difference between the mean leptin concentrations of the patient and control groups, while BMI was significantly lower in gastric cancer cases (22.9 ± 3.6 vs. 24.5 ± 2.8 ㎏/㎡, P = 0.021). There was significant association between the LEPR Lys109Arg genotype and gastric cancer risk, heterozygotes for GA genotype had been proved to increased the risk of gastric cancer, and its corresponding odds ratio was 2.926 (95% confidence interval, 1.248 to 6.861). Conclusion: Our results suggested that LEPR gene Lys109Arg polymorphism is associated with gastric cancer in Korean patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Zhang Y / 1994 / Positional cloning of the mouse obese gene and its human homologue / Nature 372 : 425 ~ 432
2. [학술지(정기간행물)] - Collins S / 1996 / Role of leptin in fat regulation / Nature 380 : 677 ~
3. [학술지(정기간행물)] - Considine RV / 1996 / Serum immunoreactive-leptin concentrations in normal-weight and obese humans / N Engl J Med 334 : 292 ~ 295
4. [학술지(정기간행물)] - Señarís R / 1997 / Synthesis of leptin in human placenta / Endocrinology 138 : 4501 ~ 4504
5. [학술지(정기간행물)] - Jin L / 1999 / Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation / J Clin Endocrinol Metab 84 : 2903 ~ 2911
2. [학술지(정기간행물)] - Collins S / 1996 / Role of leptin in fat regulation / Nature 380 : 677 ~
3. [학술지(정기간행물)] - Considine RV / 1996 / Serum immunoreactive-leptin concentrations in normal-weight and obese humans / N Engl J Med 334 : 292 ~ 295
4. [학술지(정기간행물)] - Señarís R / 1997 / Synthesis of leptin in human placenta / Endocrinology 138 : 4501 ~ 4504
5. [학술지(정기간행물)] - Jin L / 1999 / Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation / J Clin Endocrinol Metab 84 : 2903 ~ 2911
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Mineral Elements Bio-Accessibility and Antioxidant Indices of Blanched Basella rubra at Different Phases of in vitro Gastrointestinal Digestion
Sule Ola Salawu
,
Bukola Eugenia Olukemi
,
Ikuosho Cha
외 2명
Preventive Nutrition and Food Science
2018
.03
Single aptamer-based bio-chemo-mechanically hybrid system for capturing of target biomolecules with acoustofluidics
Raheel Ahmad
,
Ghulam Destgee
,
Muhammad Afzal
외 7명
한국가시화정보학회 학술발표대회 논문집
2017
.05
Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes
Wolfgang Ma
,
et
Preventive Nutrition and Food Science
2017
.03
Clean and Efficient Synthesis of Furfural From Xylose by Microwave-Assisted Biphasic System using Bio-Based Heterogeneous Acid Catalysts
Anh Thi Hoang Vo
,
Hong-shik Lee
,
Sangyong Kim
외 1명
청정기술
2016
.12
Expression Profiling of MLO Family Genes under Podosphaera xanthii Infection and Exogenous Application of Phytohormones in Cucumis melo L.
Jewel Howlade
,
Hoy-Taek Kim
,
Jong-In Pa
외 7명
생명과학회지
2016
.04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-514-003445574