지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.7
- 수록면
- 242 - 247 (6page)
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초록· 키워드
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Chondrocyte apoptosis has been recognized as an important factor in the pathogenesis of osteoarthritis (OA). Hydrogen peroxide(H₂O₂), which produces reactive oxygen species, reportedly induces apoptosis in chondrocytes. The ginsenoside Rb₁(G-Rb₁) is the principal component in ginseng and has been shown to have a variety of biological activities, such as anti-arthritis, anti inflammation, and anti-tumor activities. In this study, we evaluated the effects of G-Rb₁ on the mitochondrial permeability transition(MPT) and caspase-3 activity of chondrocyte apoptosis induced by H₂O₂. Cultured rat articular chondrocytes were exposed to H₂O₂ with or without G-Rb₁ and assessed for viability, MPT, Bcl-xL/Bax expression, caspase-3 activity, and apoptosis. The co-treatment with G-Rb₁ Showed ann inhibition of MPT, caspase-3 activity, and cell death. Additionally, the levels of the apoptotic protein Bax were significantly lower and the levels of the anti-apoptoic protein Bcl-xL were higher compared with H₂O₂ treatment alone. The result of this study demonstrate that G-Rb₁ protects chondrocytes against H₂O₂-induced apoptosis, at least in part via the inhibition of MPT and caspase-3 activity. These results demonstrate that G-Rb₁ is a potentially useful drug fot the treatment of OA patients.
목차
INTRODUCTION
MATERIALS AND METHODS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2013-524-003639874