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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 141 - 145 (5page)
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초록· 키워드
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The drug resistance of microorganisms isolated from laboratory animals never treated with antibiotics is being reported consistently, while the number of laboratory animals used in medicine, pharmacy, veterinary medicine, agriculture, nutrition, and environmental and health science has increased rapidly in Korea. Therefore, this study examined the development of antimicrobial resistance in bacteria isolated from laboratory animals bred in Korea. A total of 443 isolates (7 species) containing 5 Sphingomonas paucimobilis, 206 Escherichia coli, 60 Staphylococcus aureus, 15 Staphylococcus epidermidis, 77 Enterococcus faecalis, 27 Citrobacter freundii, 35 Acinetobacter baumannii were collected from the nose, intestine, bronchus and reproductive organs of ICR mice and SD rats. Of these species, Acinetobacter baumannii and Enterococcus faecalis showed significant antimicrobial resistance according to the minimum inhibition concentration (MIC) in E-test. In case of Acinetobacter baumannii, several isolates showed MIC values 16-128 ㎍/mL for cefazolin and cefoxitin, and higher resistance (128-512 ㎍/mL) to nitrofurantoin than that of standard type. Resistance to cefazolin, cefoxitin and nitrofurantoin was detected in 17.14, 20.00, and 8.57% of the Acinetobacter baumannii isolates, respectively. In addition, 44.1% of the Enterococcus faecalis isolates collected from the laboratory animals were resistant to oxacillin concentration of 16-32 ㎍/mL range, while MIC value of standard type was below oxacillin concentration of 6 ㎍/mL. These results suggest that in rodent species of laboratory animals, Acinetobacter baumannii are resistance to cefazolin, cefoxitin and nitrofurantoin, whereas those of Enterococcus faecalis were resistance to oxacillin.
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참고문헌 (12)
참고문헌 신청
1. [학술지(정기간행물)] - DuPont HL / 1987 / Use of antimicrobial agents in animal feeds: implications for human health / Rev Infect Dis 9 (3) : 447 ~ 460
2. [학술지(정기간행물)] - Kruse H / 1994 / Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments / Appl Environ Microbiol 60 (11) : 4015 ~ 4021
3. [학술지(정기간행물)] - Maejima K / 1980 / Drug resistance of organisms isolated from feces of laboratory mice and rats / Jikken Dobutsu 29 (1) : 71 ~ 75
4. [학술지(정기간행물)] - Hansen AK / 2000 / Antibiotic resistance in bacterial isolates from laboratory animal colonies naive to antibiotic treatment / Lab Anim 34 (4) : 413 ~ 422
5. [학술지(정기간행물)] - Baker CN / 1994 / Evaluation of Alamar colorimetric MIC method for antimicrobial susceptibility testing of gram-negative bacteria / J Clin Microbiol 32 (5) : 1261 ~ 1267
2. [학술지(정기간행물)] - Kruse H / 1994 / Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments / Appl Environ Microbiol 60 (11) : 4015 ~ 4021
3. [학술지(정기간행물)] - Maejima K / 1980 / Drug resistance of organisms isolated from feces of laboratory mice and rats / Jikken Dobutsu 29 (1) : 71 ~ 75
4. [학술지(정기간행물)] - Hansen AK / 2000 / Antibiotic resistance in bacterial isolates from laboratory animal colonies naive to antibiotic treatment / Lab Anim 34 (4) : 413 ~ 422
5. [학술지(정기간행물)] - Baker CN / 1994 / Evaluation of Alamar colorimetric MIC method for antimicrobial susceptibility testing of gram-negative bacteria / J Clin Microbiol 32 (5) : 1261 ~ 1267
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UCI(KEPA) : I410-ECN-0101-2013-510-002637181